Penetrating keratoplasty: indications over a 10 year period

Aims: To determine the indications for penetrating keratoplasty (PK) at the Corneoplastic Unit and Eye Bank, UK, a tertiary referral centre, over a 10 year period. Methods: Records of all patients who underwent PK at our institution between 1990 and 1999 were reviewed retrospectively. Of the 1096 pr...

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Published in:British journal of ophthalmology 2004-08, Vol.88 (8), p.998-1001
Main Authors: Al-Yousuf, N, Mavrikakis, I, Mavrikakis, E, Daya, S M
Format: Article
Language:English
Subjects:
Bacterial infections
Biological and medical sciences
Cataracts
Clinical Science - Scientific Reports
cornea
Female
Fuchs' Endothelial Dystrophy - surgery
herpes
herpes simplex virus
Herpes viruses
Hospitals
HSV
Humans
indications
Infections
Keratitis, Herpetic - surgery
Keratoconus - surgery
keratoplasty
Keratoplasty, Penetrating
Male
Males
Medical sciences
Middle Aged
PBK
penetrating keratoplasty
pseudophakic bullous keratopathy
Reoperation
Retrospective Studies
Sex Factors
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the eye and orbit
Surgical techniques
Transplants & implants
Trends
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Mavrikakis, I
Mavrikakis, E
Daya, S M
description Aims: To determine the indications for penetrating keratoplasty (PK) at the Corneoplastic Unit and Eye Bank, UK, a tertiary referral centre, over a 10 year period. Methods: Records of all patients who underwent PK at our institution between 1990 and 1999 were reviewed retrospectively. Of the 1096 procedures performed in this period, 784 records were available for evaluation (72%). Results: Regrafting was the most common indication, accounting for 40.9% of all cases. Keratoconus was the second most common indication (15%), followed by Fuchs’ endothelial dystrophy (9.3%), pseudophakic bullous keratopathy (7.6%), and viral keratitis (5.9%), which included both herpes simplex and herpes zoster and showed a statistically significant decreasing trend using regression analysis (p
doi_str_mv 10.1136/bjo.2003.031948
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Methods: Records of all patients who underwent PK at our institution between 1990 and 1999 were reviewed retrospectively. Of the 1096 procedures performed in this period, 784 records were available for evaluation (72%). Results: Regrafting was the most common indication, accounting for 40.9% of all cases. Keratoconus was the second most common indication (15%), followed by Fuchs’ endothelial dystrophy (9.3%), pseudophakic bullous keratopathy (7.6%), and viral keratitis (5.9%), which included both herpes simplex and herpes zoster and showed a statistically significant decreasing trend using regression analysis (p&lt;0.005). Among the regraft subgroup, viral keratitis accounted for 21.2% as the underlying primary diagnosis. The most common cause for graft failure in the regraft subgroup was endothelial failure (41.8%). Conclusion: Regrafting is the leading indication for PK; viral disease—although declining—is the leading primary diagnosis.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjo.2003.031948</identifier><identifier>PMID: 15258012</identifier><identifier>CODEN: BJOPAL</identifier><language>eng</language><publisher>BMA House, Tavistock Square, London, WC1H 9JR: BMJ Publishing Group Ltd</publisher><subject>Bacterial infections ; Biological and medical sciences ; Cataracts ; Clinical Science - Scientific Reports ; cornea ; Female ; Fuchs' Endothelial Dystrophy - surgery ; herpes ; herpes simplex virus ; Herpes viruses ; Hospitals ; HSV ; Humans ; indications ; Infections ; Keratitis, Herpetic - surgery ; Keratoconus - surgery ; keratoplasty ; Keratoplasty, Penetrating ; Male ; Males ; Medical sciences ; Middle Aged ; PBK ; penetrating keratoplasty ; pseudophakic bullous keratopathy ; Reoperation ; Retrospective Studies ; Sex Factors ; Surgery (general aspects). Transplantations, organ and tissue grafts. 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Methods: Records of all patients who underwent PK at our institution between 1990 and 1999 were reviewed retrospectively. Of the 1096 procedures performed in this period, 784 records were available for evaluation (72%). Results: Regrafting was the most common indication, accounting for 40.9% of all cases. Keratoconus was the second most common indication (15%), followed by Fuchs’ endothelial dystrophy (9.3%), pseudophakic bullous keratopathy (7.6%), and viral keratitis (5.9%), which included both herpes simplex and herpes zoster and showed a statistically significant decreasing trend using regression analysis (p&lt;0.005). Among the regraft subgroup, viral keratitis accounted for 21.2% as the underlying primary diagnosis. The most common cause for graft failure in the regraft subgroup was endothelial failure (41.8%). Conclusion: Regrafting is the leading indication for PK; viral disease—although declining—is the leading primary diagnosis.</description><subject>Bacterial infections</subject><subject>Biological and medical sciences</subject><subject>Cataracts</subject><subject>Clinical Science - Scientific Reports</subject><subject>cornea</subject><subject>Female</subject><subject>Fuchs' Endothelial Dystrophy - surgery</subject><subject>herpes</subject><subject>herpes simplex virus</subject><subject>Herpes viruses</subject><subject>Hospitals</subject><subject>HSV</subject><subject>Humans</subject><subject>indications</subject><subject>Infections</subject><subject>Keratitis, Herpetic - surgery</subject><subject>Keratoconus - surgery</subject><subject>keratoplasty</subject><subject>Keratoplasty, Penetrating</subject><subject>Male</subject><subject>Males</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>PBK</subject><subject>penetrating keratoplasty</subject><subject>pseudophakic bullous keratopathy</subject><subject>Reoperation</subject><subject>Retrospective Studies</subject><subject>Sex Factors</subject><subject>Surgery (general aspects). 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Methods: Records of all patients who underwent PK at our institution between 1990 and 1999 were reviewed retrospectively. Of the 1096 procedures performed in this period, 784 records were available for evaluation (72%). Results: Regrafting was the most common indication, accounting for 40.9% of all cases. Keratoconus was the second most common indication (15%), followed by Fuchs’ endothelial dystrophy (9.3%), pseudophakic bullous keratopathy (7.6%), and viral keratitis (5.9%), which included both herpes simplex and herpes zoster and showed a statistically significant decreasing trend using regression analysis (p&lt;0.005). Among the regraft subgroup, viral keratitis accounted for 21.2% as the underlying primary diagnosis. The most common cause for graft failure in the regraft subgroup was endothelial failure (41.8%). Conclusion: Regrafting is the leading indication for PK; viral disease—although declining—is the leading primary diagnosis.</abstract><cop>BMA House, Tavistock Square, London, WC1H 9JR</cop><pub>BMJ Publishing Group Ltd</pub><pmid>15258012</pmid><doi>10.1136/bjo.2003.031948</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
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ispartof British journal of ophthalmology, 2004-08, Vol.88 (8), p.998-1001
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1468-2079
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1772260
source PubMed Central (Open Access)
subjects Bacterial infections
Biological and medical sciences
Cataracts
Clinical Science - Scientific Reports
cornea
Female
Fuchs' Endothelial Dystrophy - surgery
herpes
herpes simplex virus
Herpes viruses
Hospitals
HSV
Humans
indications
Infections
Keratitis, Herpetic - surgery
Keratoconus - surgery
keratoplasty
Keratoplasty, Penetrating
Male
Males
Medical sciences
Middle Aged
PBK
penetrating keratoplasty
pseudophakic bullous keratopathy
Reoperation
Retrospective Studies
Sex Factors
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the eye and orbit
Surgical techniques
Transplants & implants
Trends
title Penetrating keratoplasty: indications over a 10 year period
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