Serum paraoxonase activity is decreased in the active stage of Behçet’s disease

Aims: To evaluate paraoxonase1 (PON1) activities and malondialdehyde (MDA) levels, one of the end products of lipid peroxidation induced by reactive oxygen species in patients with Behçet’s disease (BD) in the active stage. Methods: Serum MDA levels and PON1 levels were measured spectrophotometrical...

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Bibliographic Details
Published in:British journal of ophthalmology 2004-10, Vol.88 (10), p.1256-1258
Main Authors: Karakucuk, S, Baskol, G, Oner, A O, Baskol, M, Mirza, E, Ustdal, M
Format: Article
Language:English
Subjects:
Adult
Aryldialkylphosphatase - blood
Behcet Syndrome - blood
Behcet Syndrome - enzymology
Behçet’s disease
Biological and medical sciences
Clinical Science - Scientific Reports
Female
HDL
high density lipoprotein
Humans
Lipid Peroxidation
Male
malondialdehyde
Malondialdehyde - blood
MDA
Medical sciences
Middle Aged
paraoxonase 1
paraoxonase1
PON1
reactive oxygen species
ROS
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
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Summary:Aims: To evaluate paraoxonase1 (PON1) activities and malondialdehyde (MDA) levels, one of the end products of lipid peroxidation induced by reactive oxygen species in patients with Behçet’s disease (BD) in the active stage. Methods: Serum MDA levels and PON1 levels were measured spectrophotometrically in 16 patients with BD in the active stage of the disease and in 15 healthy subjects who constituted the control group. Results: In the BD group, median (range) serum PON1 and MDA levels were 149.64 U/l (88.02–281.68) and 1.21 nmol/ml (0.90–3.42), respectively. In the control group, median (range) serum PON1 and MDA levels were 206.86 U/l (114.43–422.52) and 0.72 nmol/ml (0.50–1.12), respectively. There was a statistically significant decrease in serum PON1 levels (p = 0.02) and an increase in serum MDA levels (p
ISSN:0007-1161
1468-2079
DOI:10.1136/bjo.2004.043398