Photodynamic therapy of circumscribed choroidal haemangioma

Aim: To evaluate efficacy of verteporfin ocular photodynamic therapy (PDT) in treatment of 10 patients with a symptomatic circumscribed choroidal haemangioma. Design: Prospective non-randomised, interventional case series and critical review of previously published studies. Methods: 10 consecutive p...

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Bibliographic Details
Published in:British journal of ophthalmology 2004-11, Vol.88 (11), p.1414-1418
Main Authors: Singh, A D, Kaiser, P K, Sears, J E, Gupta, M, Rundle, P A, Rennie, I G
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Choroid Neoplasms - drug therapy
Choroid Neoplasms - pathology
choroidal haemangioma
choroidal neoplasms
Clinical Science - Scientific Reports
Diseases of the eye
Female
Fluorescein Angiography
Hemangioma - drug therapy
Hemangioma - pathology
Humans
Macular degeneration
Male
Medical sciences
Middle Aged
PDT
Photochemotherapy - methods
Photodynamic therapy
Photosensitizing Agents - therapeutic use
Porphyrins - therapeutic use
Prospective Studies
Radiation therapy
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Studies
transpupillary thermotherapy
Treatment Outcome
TTT
Tumors
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Summary:Aim: To evaluate efficacy of verteporfin ocular photodynamic therapy (PDT) in treatment of 10 patients with a symptomatic circumscribed choroidal haemangioma. Design: Prospective non-randomised, interventional case series and critical review of previously published studies. Methods: 10 consecutive patients (seven primary, two failed transpupillary thermotherapy (TTT), and one failed external beam radiotherapy) with symptomatic circumscribed choroidal haemangioma were treated using verteporfin 6 mg/m2 given as an intravenous infusion over 10 minutes. Diode laser (690 nm) with an intensity of 600 mW/cm2 for 83 seconds (50 J/cm2) was applied 5 minutes after completion of infusion. Single or multiple partially overlapping spots were applied based on the tumour basal dimensions. Periodic follow up with ophthalmoscopy, ultrasonography, and angiographic studies was performed. Results: All 10 patients showed evidence of regression with flattening of tumour, resolution of subretinal fluid, and reduction of choroidal vasculature on angiograms. The visual acuity either improved or remained stable in eight (80%) patients. Visual loss due to delayed choroidal atrophy was seen in two patients. Conclusions: Although verteporfin PDT is an effective treatment for management of symptomatic circumscribed choroidal haemangioma, delayed treatment related effects can lead to visual loss.
ISSN:0007-1161
1468-2079
DOI:10.1136/bjo.2004.044396