Augmented trabeculectomy in paediatric glaucoma

Aims: To report the experience with trabeculectomy augmented with mitomycin C and 5-fluorouracil for the treatment of paediatric glaucoma. Methods: Retrospective, interventional case series design was used. The sample included 17 children (29 eyes) with primary (19 eyes) or secondary (10 eyes) glauc...

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Bibliographic Details
Published in:British journal of ophthalmology 2005-02, Vol.89 (2), p.165-168
Main Authors: Ehrlich, R, Snir, M, Lusky, M, Weinberger, D, Friling, R, Gaton, D D
Format: Article
Language:English
Subjects:
5-fluorouracil
5-FU
antimetabolites
Antimetabolites - therapeutic use
Biological and medical sciences
Child
Child, Preschool
children
Clinical Science - Extended Reports
Combined Modality Therapy - methods
Female
Fluorouracil - therapeutic use
Glaucoma
Glaucoma - drug therapy
Glaucoma - physiopathology
Glaucoma - surgery
Glaucoma and intraocular pressure
Humans
Infant
Intraocular Pressure - physiology
Life Tables
Male
Medical sciences
Mitomycin - therapeutic use
mitomycin C
MMC
Ophthalmology
paediatric glaucoma
Postoperative Complications - etiology
Refractive Errors - physiopathology
Reoperation
Retrospective Studies
trabeculectomy
Trabeculectomy - methods
Treatment Outcome
Visual Acuity - physiology
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Summary:Aims: To report the experience with trabeculectomy augmented with mitomycin C and 5-fluorouracil for the treatment of paediatric glaucoma. Methods: Retrospective, interventional case series design was used. The sample included 17 children (29 eyes) with primary (19 eyes) or secondary (10 eyes) glaucoma who were treated with augmented trabeculectomy as the primary procedure between 1990 and 2002. Data were collected on age and family history, preoperative and end of follow up intraocular pressure, cup/disc ratio (evaluated by drawing), visual acuity, complications, and post-surgery treatment. Results: Patient age at surgery ranged from 1 month to 8 years; most patients (n = 14, 82.3%) were aged less than 1 year (range 1 month–8 months, mean 3.95 (SD 2.56) months); three patients (17.7%) were aged 3, 5, and 8 years. The duration of follow up was 3–120 months (mean 46 months). Intraocular pressure significantly improved from 21 mm Hg to 60 mm Hg (mean 33.1 (10) mm Hg) before surgery to 6–26 mm Hg (mean 17.1 (6) mm Hg) after, (p
ISSN:0007-1161
1468-2079
DOI:10.1136/bjo.2004.046037