A pilot study on the use of a perfluorohexyloctane/silicone oil solution as a heavier than water internal tamponade agent

• Published in: British journal of ophthalmology 2005-06, Vol.89 (6), p.662-665
• Main Authors: Wong, D, Van Meurs, J C, Stappler, T, Groenewald, C, Pearce, I A, McGalliard, J N, Manousakis, E, Herbert, E N
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Clinical Science - Scientific Reports; Drug Combinations; epiretinal membranes; ERM; Female; Fluorocarbons - adverse effects; Fluorocarbons - pharmacokinetics; Fluorocarbons - therapeutic use; Humans; Male; Medical sciences; Middle Aged; Ocular Hypertension - etiology; pars plana vitrectomy; perfluorocarbon liquids; perfluorohexyloctane; PFCL; Pilot Projects; Postoperative Care - methods; Postoperative Complications; Posture; PPV; proliferative vitreoretinopathy; Prospective Studies; PVR; Recurrence; retinal detachment; Retinal Detachment - physiopathology; Retinal Detachment - surgery; retinal detachments; silicone oil; Silicone Oils - adverse effects; Silicone Oils - pharmacokinetics; Silicone Oils - therapeutic use; SiO; Specific Gravity; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the eye and orbit; Treatment Outcome; Visual Acuity; Vitrectomy - methods; Vitreoretinopathy, Proliferative - physiopathology; Vitreoretinopathy, Proliferative - surgery
• ISSN: 0007-1161; 1468-2079
• DOI: 10.1136/bjo.2004.055178

Aims: To report a prospective two centred non-comparative interventional pilot study of a solution of perfluorohexyloctane and silicone oil (Densiron-68) as a heavier than water internal tamponade. Methods: 42 consecutive patients were recruited. The indications include proliferative vitreoretinopathy, retinal detachments arising from inferior retinal breaks, and inability to posture. Results: The success rate with one operation using Densiron was 81% and with further surgery 93%. At the end of the study all tamponade agents were removed in 90% of patients. Visual acuity improved from mean logMAR of 1.41 (SD 0.64) to 0.94 (SD 0.57), p = 0.001. There was little evidence of dispersion and excessive inflammation. Conclusion: This new tamponade agent is being compared to conventional silicone oil in a prospective international randomised trial.