Successful treatment of Wegener’s granulomatosis associated scleritis with rituximab

Comment Rituximab is a humanised monoclonal antibody against the CD20 antigen that is expressed on the cell surface during early pre-B cell development and persists through all stages of B cell differentiation. 4 It results in rapid depletion of CD20 positive B lymphocytes from the circulating blood...

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Bibliographic Details
Published in:British journal of ophthalmology 2005-11, Vol.89 (11), p.1542-1542
Main Authors: Cheung, C M G, Murray, P I, Savage, C O S
Format: Article
Language:English
Subjects:
Adult
Antibodies, Monoclonal - therapeutic use
Antibodies, Monoclonal, Murine-Derived
Antigens
Antigens, CD20 - immunology
Granulomatosis with Polyangiitis - complications
Humans
Letter
Lymphoma
Male
Rituximab
scleritis
Scleritis - drug therapy
Wegener’s granulomatosis
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Summary:Comment Rituximab is a humanised monoclonal antibody against the CD20 antigen that is expressed on the cell surface during early pre-B cell development and persists through all stages of B cell differentiation. 4 It results in rapid depletion of CD20 positive B lymphocytes from the circulating blood and is well tolerated. [...]in this case the prompt improvement was attributed to rituximab, rather than cyclophosphamide.
ISSN:0007-1161
1468-2079
DOI:10.1136/bjo.2005.075689