Reduction in Preterm Delivery and Neonatal Mortality after the Introduction of Antenatal Cotrimoxazole Prophylaxis among HIV-Infected Women with Low CD4 Cell Counts

BackgroundCotrimoxazole prophylaxis is recommended for subgroups of human immunodeficiency virus (HIV)–infected adults and children to reduce all-cause morbidity and mortality. We investigated whether antenatal cotrimoxazole prophylaxis begun during pregnancy for HIV-infected pregnant women with low...

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Bibliographic Details
Published in:The Journal of infectious diseases 2006-12, Vol.194 (11), p.1510-1518
Main Authors: Walter, Jan, Mwiya, Mwiya, Scott, Nancy, Kasonde, Prisca, Sinkala, Moses, Kankasa, Chipepo, Kauchali, Shuaib, Aldrovandi, Grace M., Thea, Donald M., Kuhn, Louise
Format: Article
Language:English
Subjects:
Adult
AIDS-Related Opportunistic Infections - prevention & control
Anti-Infective Agents - therapeutic use
Birth weight
CD4 Lymphocyte Count
Chorioamnionitis
Female
Gestational age
Health care delivery
HIV Infections - drug therapy
HIV Infections - immunology
HIV/AIDS
Human immunodeficiency virus
Humans
Infant
Infant Mortality
Infant, Low Birth Weight
Infant, Newborn
Infants
Infections
Mortality
Neonatal mortality
Pregnancy
Pregnancy Complications, Infectious - drug therapy
Pregnancy Complications, Infectious - prevention & control
Pregnancy Outcome
Premature Birth - prevention & control
Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use
Women
Zambia
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Summary:BackgroundCotrimoxazole prophylaxis is recommended for subgroups of human immunodeficiency virus (HIV)–infected adults and children to reduce all-cause morbidity and mortality. We investigated whether antenatal cotrimoxazole prophylaxis begun during pregnancy for HIV-infected pregnant women with low CD4 cell counts would affect birth outcomes MethodsCotrimoxazole prophylaxis was introduced as a routine component of antenatal care for HIV-infected women with CD4 cell counts
ISSN:0022-1899
1537-6613
DOI:10.1086/508996