Increased urinary excretion of aquaporin 2 in patients with liver cirrhosis

Background and aim: Water retention is a major clinical problem in patients with liver cirrhosis. Recent research suggests that renal aquaporins may be pathophysiologically involved in this condition. The aim of the present cross sectional study of patients with liver cirrhosis was to determine if 2...

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Bibliographic Details
Published in:Gut 2003-08, Vol.52 (8), p.1194-1199
Main Authors: Ivarsen, P, Frøkiær, J, Aagaard, N K, Hansen, E F, Bendtsen, F, Nielsen, S, Vilstrup, H
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Aged, 80 and over
Analysis
AQP2
Aquaporin 2
Aquaporin 6
Aquaporins
Aquaporins - urine
Biological and medical sciences
cirrhosis
ClH2O
Composition
Creatinine - blood
Cross-Sectional Studies
Denmark
Diagnosis
Diseases
Evaluation
Female
free water clearance
galactose elimination capacity
Gastroenterology. Liver. Pancreas. Abdomen
GEC
Humans
Liver
Liver cirrhosis
Liver Cirrhosis - blood
Liver Cirrhosis - urine
Liver diseases
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Osmolar Concentration
Other diseases. Semiology
Patients
Permeability
Physiological aspects
Renal manifestations of general diseases
Retention
Rodents
serum osmolality
Sosm
Statistics
T-TBS
TBS
TBS buffer and Tween
Tris buffered saline
Uosm
Urine
urine osmolality
urine volume
Vasopressins - blood
Water-Electrolyte Balance
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Summary:Background and aim: Water retention is a major clinical problem in patients with liver cirrhosis. Recent research suggests that renal aquaporins may be pathophysiologically involved in this condition. The aim of the present cross sectional study of patients with liver cirrhosis was to determine if 24 hour urinary excretion of renal aquaporin 2 (AQP2) differed from that of healthy control subjects and if such excretion was related to the severity of liver disease and to the patient’s water balance. Results: Twenty four hour urinary excretion of AQP2 and free water clearance were measured in 33 stable cirrhosis patients on usual medication and in eight healthy subjects. AQP2 excretion, quantitated by immunoblotting, was eight times higher in cirrhosis patients than in controls (0.167 (0.270) U/day v 0.021 (0.017); p
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.52.8.1194