No genetic association between EPHX1 and Crohn’s disease

The Tyr allele frequencies of 0.70 and 0.68 obtained for cases and controls, respectively, were very similar to the corresponding values of 0.71 and 0.70, as reported by Cuthbert et al. [...]in answer to the question as posed by Cuthbert et al: "Genetic association between EPHX1 and Crohn'...

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Bibliographic Details
Published in:Gut 2005-11, Vol.54 (11), p.1659-1660
Main Authors: Peters, W H M, van der Logt, E M J, te Morsche, R H M, Roelofs, H M J, de Jong, D J, Naber, T H J
Format: Article
Language:English
Subjects:
Bowel disease
Crohn Disease - genetics
Crohn's disease
Deoxyribonucleic acid
DNA
EPHX1
Epoxide Hydrolases - genetics
Genes
Genetic Predisposition to Disease
Humans
Letter
Polymorphism, Genetic
Studies
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Summary:The Tyr allele frequencies of 0.70 and 0.68 obtained for cases and controls, respectively, were very similar to the corresponding values of 0.71 and 0.70, as reported by Cuthbert et al. [...]in answer to the question as posed by Cuthbert et al: "Genetic association between EPHX1 and Crohn's disease: population stratification, genotyping error, or random chance?", we can conclude that a genotyping error was responsible for our earlier published association between the EPHX1 Tyr113His polymorphism and Crohn's disease. 1 We now clearly state that our revised data do not support an association between this EPHX1 polymorphism and Crohn's disease.
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.2005.076422