European and North American populations should be screened for coeliac disease

EARLY DETECTION CD can manifest with a previously unsuspected range of clinical presentations, including the typical malabsorption syndrome (chronic diarrhoea, weight loss, abdominal distension) and a spectrum of symptoms potentially affecting any organ or body system. 4- 6 As CD is often atypical o...

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Bibliographic Details
Published in:Gut 2003-02, Vol.52 (2), p.168-171
Main Author: Fasano, A
Format: Article
Language:English
Subjects:
Biological and medical sciences
Celiac disease
Celiac Disease - diagnosis
Celiac Disease - diet therapy
Celiac Disease - epidemiology
coeliac disease
Debate
Diagnosis
Disease
Europe - epidemiology
Gastroenterology. Liver. Pancreas. Abdomen
Gluten
Humans
Mass Screening - methods
Medical sciences
Medical screening
Morbidity
Mortality
North America - epidemiology
Other diseases. Semiology
Pathogenesis
Prevalence
screening
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Description
Summary:EARLY DETECTION CD can manifest with a previously unsuspected range of clinical presentations, including the typical malabsorption syndrome (chronic diarrhoea, weight loss, abdominal distension) and a spectrum of symptoms potentially affecting any organ or body system. 4- 6 As CD is often atypical or even clinically silent, the vast majority of cases remain undiagnosed for many years and exposed to the risk of long term complications. 7 PREVALENCE Analysis of the world codistribution of the two key components (HLA genes and grains) involved in CD pathogenesis 2 would predict a wide distribution of the disease, both in regions where CD is described as a frequent disorder (that is, Europe) 6 and in areas where the disease has been historically considered rare (that is, the USA).
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.52.2.168