Influenza Virus Database (IVDB): an integrated information resource and analysis platform for influenza virus research

Frequent outbreaks of highly pathogenic avian influenza and the increasing data available for comparative analysis require a central database specialized in influenza viruses (IVs). We have established the Influenza Virus Database (IVDB) to integrate information and create an analysis platform for g...

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Bibliographic Details
Published in:Nucleic acids research 2007-01, Vol.35 (suppl-1), p.D376-D380
Main Authors: Chang, Suhua, Zhang, Jiajie, Liao, Xiaoyun, Zhu, Xinxing, Wang, Dahai, Zhu, Jiang, Feng, Tao, Zhu, Baoli, Gao, George F, Wang, Jian, Yang, Huanming, Yu, Jun, Wang, Jing
Format: Article
Language:English
Subjects:
Databases, Genetic
Genes, Viral
Genome, Viral
Genomics
Influenza A virus
Influenza A virus - genetics
Internet
Orthomyxoviridae - classification
Orthomyxoviridae - genetics
Phylogeny
Polymorphism, Genetic
Software
Systems Integration
User-Computer Interface
Viral Proteins - chemistry
Viral Proteins - genetics
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Summary:Frequent outbreaks of highly pathogenic avian influenza and the increasing data available for comparative analysis require a central database specialized in influenza viruses (IVs). We have established the Influenza Virus Database (IVDB) to integrate information and create an analysis platform for genetic, genomic, and phylogenetic studies of the virus. IVDB hosts complete genome sequences of influenza A virus generated by Beijing Institute of Genomics (BIG) and curates all other published IV sequences after expert annotation. Our Q-Filter system classifies and ranks all nucleotide sequences into seven categories according to sequence content and integrity. IVDB provides a series of tools and viewers for comparative analysis of the viral genomes, genes, genetic polymorphisms and phylogenetic relationships. A search system has been developed for users to retrieve a combination of different data types by setting search options. To facilitate analysis of global viral transmission and evolution, the IV Sequence Distribution Tool (IVDT) has been developed to display the worldwide geographic distribution of chosen viral genotypes and to couple genomic data with epidemiological data. The BLAST, multiple sequence alignment and phylogenetic analysis tools were integrated for online data analysis. Furthermore, IVDB offers instant access to pre-computed alignments and polymorphisms of IV genes and proteins, and presents the results as SNP distribution plots and minor allele distributions. IVDB is publicly available at http://influenza.genomics.org.cn
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gkl779