Tracking the dynamics of T‐cell activation in response to Salmonella infection

Summary Despite the current availability of Salmonella vaccines, typhoid fever remains a significant public health problem in developing countries. A greater understanding of T‐cell activation and the development of immunological memory during Salmonella infection should lead to the development of m...

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Bibliographic Details
Published in:Immunology 2005-04, Vol.114 (4), p.450-458
Main Authors: Ravindran, Rajesh, McSorley, Stephen J.
Format: Article
Language:English
Subjects:
Animals
B-Lymphocytes - immunology
bacteria
Developing Countries
Humans
Immunologic Memory
Lymphocyte Activation
memory
Mice
Mice, Mutant Strains
Models, Animal
Review
Salmonella
Salmonella typhimurium
T cell
T-Lymphocytes - immunology
Typhoid Fever - immunology
Typhoid Fever - microbiology
Typhoid-Paratyphoid Vaccines
vaccination
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Summary:Summary Despite the current availability of Salmonella vaccines, typhoid fever remains a significant public health problem in developing countries. A greater understanding of T‐cell activation and the development of immunological memory during Salmonella infection should lead to the development of more effective prophylactic intervention. Here, we review recent literature on the initiation, expansion and memory development of T‐cell responses using the mouse model of typhoid. We pay particular attention to strategies for tracking T‐cell responses in vivo and ex vivo, and suggest models to integrate some these studies.
ISSN:0019-2805
1365-2567
DOI:10.1111/j.1365-2567.2005.02140.x