Biochemical Response of Late Rickets and Osteomalacia to a Chupatty-free Diet

Eight Pakistani children with late rickets and two Pakistani women with osteomalacia were given a chupatty-free diet for seven weeks, substituting leavened bread of lower extraction. On this diet serum calcium levels rose to normal or near normal, levels of serum inorganic phosphorus rose slightly b...

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Bibliographic Details
Published in:BMJ 1972-08, Vol.3 (5824), p.446-447
Main Authors: Ford, J. A., Colhoun, E. M., McIntosh, W. B., Dunnigan, M. G.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Alkaline Phosphatase - blood
Biochemistry
Bread
Calcium
Calcium - blood
Calcium Carbonate - therapeutic use
Calcium, Dietary
Child
Children
Diet
Diet Therapy
Female
Food, Fortified
Forts
Healing
Humans
India
Inositol - adverse effects
Male
Middle Aged
Osteomalacia
Osteomalacia - chemically induced
Osteomalacia - therapy
Pakistan
Papers and Originals
Phosphatases
Phosphorus - blood
Rickets
Rickets - chemically induced
Rickets - therapy
United Kingdom
Unleavened breads
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Summary:Eight Pakistani children with late rickets and two Pakistani women with osteomalacia were given a chupatty-free diet for seven weeks, substituting leavened bread of lower extraction. On this diet serum calcium levels rose to normal or near normal, levels of serum inorganic phosphorus rose slightly but significantly, and serum alkaline phosphatase levels showed a definite rise indicative of healing bone disease. It is concluded that the high phytate content of unleavened bread is the major cause of late rickets and osteomalacia in Pakistani and Indian communities in the United Kingdom. The simplest prophylactic measure seems to be the additional fortification with calcium carbonate of the high extraction flour used in preparing unleavened bread.
ISSN:0007-1447
0959-8138
1468-5833
DOI:10.1136/bmj.3.5824.446