Pharmacokinetics of prednisolone in children with nephrosis

The pharmacokinetics of prednisolone given intravenously were studied in 11 children with relapsed steroid responsive nephrotic syndrome, and four control subjects. The clearance of both total and unbound drug was decreased in these children and the unbound fraction of the drug in plasma was signifi...

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Bibliographic Details
Published in:Archives of disease in childhood 1990-02, Vol.65 (2), p.196-200
Main Authors: Miller, P F, Bowmer, C J, Wheeldon, J, Brocklebank, J T
Format: Article
Language:English
Subjects:
Adolescent
Adrenocortical hormones
Child
Child, Preschool
Children
Corticosteroids
Dosage and administration
Drug therapy
Female
Half-Life
Humans
Injections, Intravenous
Liver - metabolism
Male
Metabolic Clearance Rate
Nephrosis - drug therapy
Nephrosis - metabolism
Nephrotic syndrome
Pediatrics
Pharmacokinetics
Prednisolone
Prednisolone - administration & dosage
Prednisolone - pharmacokinetics
Prednisolone - therapeutic use
Prognosis
Regression Analysis
Toxicity
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Summary:The pharmacokinetics of prednisolone given intravenously were studied in 11 children with relapsed steroid responsive nephrotic syndrome, and four control subjects. The clearance of both total and unbound drug was decreased in these children and the unbound fraction of the drug in plasma was significantly correlated with the degree of hypoalbuminaemia. We conclude that changes in the clearance of prednisolone and altered protein binding might account for some of the variability in both therapeutic responses and the incidence of toxicity in patients treated with standard dosage regimens.
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.65.2.196