Endotoxin induced damage to the cochlea in guinea pigs

An apparently unique form of cochlear damage was produced in guinea pigs by perfusing the cochlea or injecting the cerebrospinal fluid with bacterial endotoxin. This developed rapidly (within two hours) and was characterised by swelling of the tectorial membrane and damage to both inner and outer ha...

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Bibliographic Details
Published in:Archives of disease in childhood 1991-02, Vol.66 (2), p.181-184
Main Authors: Tarlow, M J, Comis, S D, Osborne, M P
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Animals
Biological and medical sciences
Cerebrospinal fluid
Cochlea
Cochlea - drug effects
Cochlea - physiology
Cochlea - ultrastructure
Dexamethasone
Dexamethasone - pharmacology
Endotoxins
Endotoxins - antagonists & inhibitors
Endotoxins - toxicity
Escherichia coli
Evoked Potentials, Auditory - drug effects
Fundamental and applied biological sciences. Psychology
Guinea Pigs
Hair cells
Hair Cells, Auditory - ultrastructure
Hearing loss
Meningitis
Microscopy, Electron, Scanning
Outer hair cells
Pediatrics
Tectorial Membrane - ultrastructure
Vertebrates: nervous system and sense organs
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Summary:An apparently unique form of cochlear damage was produced in guinea pigs by perfusing the cochlea or injecting the cerebrospinal fluid with bacterial endotoxin. This developed rapidly (within two hours) and was characterised by swelling of the tectorial membrane and damage to both inner and outer hair cells, with parallel functional damage demonstrable electrophysiologically. All these changes could be attenuated by pretreatment with dexamethasone. Such endotoxin mediated lesions may be the mechanism by which hearing loss occurs in bacterial meningitis.
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.66.2.181