Screening of diabetic children for coeliac disease with antigliadin antibodies and HLA typing

IgA and IgG antigliadin antibodies were measured in 498 patients with insulin dependent diabetes mellitus and no history of intestinal malabsorption. Thirty patients had abnormal concentrations of antigliadin antibodies; 22 of these had an intestinal biopsy carried out and 16 of the 22 had subtotal...

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Bibliographic Details
Published in:Archives of disease in childhood 1991-04, Vol.66 (4), p.491-494
Main Authors: Barera, G, Bianchi, C, Calisti, L, Cerutti, F, Dammacco, F, Frezza, E, Illeni, M T, Mistura, L, Pocecco, M, Prisco, F
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antibodies - analysis
Atrophy
Biological and medical sciences
Biopsy
Celiac disease
Celiac Disease - complications
Celiac Disease - diagnosis
Celiac Disease - immunology
Child
Child, Preschool
Diabetes
Diabetes mellitus (insulin dependent)
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - immunology
Endocrinopathies
Female
Gliadin
Gliadin - immunology
Histocompatibility antigen HLA
Histocompatibility Testing
HLA-B8 Antigen - analysis
HLA-DQ Antigens - analysis
HLA-DR3 Antigen - analysis
Humans
Immunoglobulin A
Immunoglobulin A - immunology
Immunoglobulin G
Immunoglobulin G - immunology
Infant
Insulin
Intestine
Malabsorption
Male
Medical sciences
Pediatrics
Tissue typing
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Description
Summary:IgA and IgG antigliadin antibodies were measured in 498 patients with insulin dependent diabetes mellitus and no history of intestinal malabsorption. Thirty patients had abnormal concentrations of antigliadin antibodies; 22 of these had an intestinal biopsy carried out and 16 of the 22 had subtotal villous atrophy suggestive of coeliac disease (prevalence 3.2%). There were no significant differences between patients with coeliac disease and diabetes and diabetic patients with normal IgA antigliadin antibodies in any of the nutritional variables measured, duration of diabetes, and mean insulin requirement. The mean age of onset of diabetes and attainment of expected height for age were both significantly lower in the patients with both diseases. Typing HLA classes I and II was done in 242 patients. The incidence of HLA-B8, DR3, and DQW2, which are commonly associated with both the diseases, is increased when both are present.
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.66.4.491