Impaired Water Handling in Chronic Airways Disease

The response to a standard water load (20 ml/kg body weight) was studied in 20 patients with chronic obstructive airways disease and in 13 healthy subjects. The percentage of the water load excreted in four hours was significantly lower in the patients (mean 51%) than in the controls (mean 106%). Th...

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Bibliographic Details
Published in:BMJ 1971-06, Vol.2 (5761), p.561-563
Main Authors: White, R. J., Woodings, D. F.
Format: Article
Language:English
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Summary:The response to a standard water load (20 ml/kg body weight) was studied in 20 patients with chronic obstructive airways disease and in 13 healthy subjects. The percentage of the water load excreted in four hours was significantly lower in the patients (mean 51%) than in the controls (mean 106%). The maximum urine flow, osmolar clearance, free water clearance, and creatinine clearance were also significantly reduced in the patients. There was a significant inverse correlation between the percentage of load passed and the arterial PCO2 (r = -0·798). Among the several possible causes of the reduced excretion of water which are discussed is a direct effect of hypercapnia.
ISSN:0007-1447
0959-8138
1468-5833
DOI:10.1136/bmj.2.5761.561