Prostaglandins and Glaucoma

Human aqueous humour was found to contain a substance which contracted the rat stomach strip. The mean activity was significantly higher in specimens from open angle glaucoma cases than in specimens from patients with cataract. The pharmacological and chromatographic properties of the active materia...

Full description

Saved in:
Bibliographic Details
Published in:BMJ 1971-09, Vol.3 (5775), p.615-617
Main Authors: Wyllie, Anne M., Wyllie, John H.
Format: Article
Language:English
Subjects:
Aged
Aqueous humor
Aqueous Humor - analysis
Biological Assay
Cadaver
Cadavers
Cataract - metabolism
Cataracts
Chromatography, Thin Layer
Female
Glaucoma
Glaucoma - etiology
Glaucoma - metabolism
Humans
Male
Middle Aged
Open angle glaucoma
Papers and Originals
Pharmacology
Physiology
Prostaglandins
Prostaglandins - analysis
Solvents
Stomach
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Human aqueous humour was found to contain a substance which contracted the rat stomach strip. The mean activity was significantly higher in specimens from open angle glaucoma cases than in specimens from patients with cataract. The pharmacological and chromatographic properties of the active material were studied in aqueous humour obtained from cadavers; activity seemed to be due to prostaglandin E1. These results suggest that prostaglandin E1 may play some part in the aetiology of open angle glaucoma.
ISSN:0007-1447
0959-8138
1468-5833
DOI:10.1136/bmj.3.5775.615