Recurrent Thyrotoxicosis after Subtotal Thyroidectomy

A study of patients with recurrent thyrotoxicosis after subtotal thyroidectomy has shown that the operation has a profound effect on the natural history of Graves's disease. It is followed by pronounced changes in the immunological features of the disease, with a fall in the prevalence of serum...

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Bibliographic Details
Published in:BMJ 1971-10, Vol.4 (5782), p.258-261
Main Authors: Hedley, Anthony J., Ross, Iain P., Beck, J. Swanson, Donald, David, Albert-Recht, F., Michie, W., Crooks, James
Format: Article
Language:English
Subjects:
Antibodies
Autoantibodies
Autoantibodies - analysis
Blood
Disease remission
Gastric Mucosa - immunology
Graves disease
Graves Disease - immunology
Graves Disease - surgery
Humans
Hyperthyroidism
Immunoglobulin G - analysis
Immunology
Iodine Radioisotopes
Long-Acting Thyroid Stimulator - analysis
Papers and Originals
Prospective Studies
Recurrence
Retrospective Studies
Thyroid gland
Thyroid Gland - immunology
Thyroidectomy
Thyrotoxicosis
Triiodothyronine
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Summary:A study of patients with recurrent thyrotoxicosis after subtotal thyroidectomy has shown that the operation has a profound effect on the natural history of Graves's disease. It is followed by pronounced changes in the immunological features of the disease, with a fall in the prevalence of serum thyroid autoantibodies, including the long-acting thyroid stimulator. Thyroid suppression returns to normal in 70% of patients. The treatment produces two populations of patients. In the larger group there is a permanent remission of the disease process. In the smaller group the disease process persists and, consequently, recurrent hyperthyroidism may develop. The mechanism of the change in the larger group of patients probably has an immunological basis.
ISSN:0007-1447
0959-8138
1468-5833
DOI:10.1136/bmj.4.5782.258