Acetyl- l-carnitine prevents and reduces paclitaxel-induced painful peripheral neuropathy

This study examines the potential efficacy of acetyl- l-carnitine (ALC) to prevent and treat paclitaxel-induced pain. Rats received four intraperitoneal (i.p.) injections of 2 mg/kg paclitaxel on alternate days which, following a short delay induced marked mechanical hypersensitivity. Daily administ...

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Bibliographic Details
Published in:Neuroscience letters 2006-04, Vol.397 (3), p.219-223
Main Authors: Flatters, Sarah J.L., Xiao, Wen-Hua, Bennett, Gary J.
Format: Article
Language:English
Subjects:
Acetylcarnitine - administration & dosage
Acetylcarnitine - therapeutic use
Administration, Oral
ALC
ALCAR
Animals
Antineoplastic Agents, Phytogenic - adverse effects
Biological and medical sciences
Chemotherapy
Fundamental and applied biological sciences. Psychology
l-Acetylcarnitine
Male
Paclitaxel
Paclitaxel - adverse effects
Pain
Pain - chemically induced
Pain - prevention & control
Pain Measurement
Peripheral Nervous System Diseases - chemically induced
Peripheral Nervous System Diseases - prevention & control
Rats
Rats, Sprague-Dawley
Vertebrates: nervous system and sense organs
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Summary:This study examines the potential efficacy of acetyl- l-carnitine (ALC) to prevent and treat paclitaxel-induced pain. Rats received four intraperitoneal (i.p.) injections of 2 mg/kg paclitaxel on alternate days which, following a short delay induced marked mechanical hypersensitivity. Daily administration of ALC (50 mg/kg and 100 mg/kg; p.o.; concurrently with paclitaxel and for 14 days afterwards) prevented the development of paclitaxel-induced pain. This effect was long lasting, for at least 3 weeks after the last dose of ALC. In a separate experiment, daily administration of ALC (100 mg/kg; p.o.; for 10 days) to rats with established paclitaxel-induced pain produced an analgesic effect. This effect dissipated shortly after ALC treatment was withdrawn. We conclude that ALC may be useful in the prevention and treatment of chemotherapy-induced painful peripheral neuropathy.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2005.12.013