Circulating endothelial cells in Kawasaki disease

summary Recent reports have demonstrated that circulating endothelial cells (CECs) are observed in several diseases with vascular injury. Because Kawasaki disease (KD) is one type of systemic vasculitis, we hypothesized that an increased number of CECs may be associated with the appearance of compli...

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Bibliographic Details
Published in:Clinical and experimental immunology 2003-03, Vol.131 (3), p.536-540
Main Authors: NAKATANI, K., TAKESHITA, S., TSUJIMOTO, H., KAWAMURA, Y., TOKUTOMI, T., SEKINE, I.
Format: Article
Language:English
Subjects:
Acute Disease
Biological and medical sciences
Blood Cells - pathology
Cell Count
Child
Child, Preschool
circulating endothelial cells
Clinical Studies
endothelial progenitor cell
Endothelium, Vascular - pathology
Female
General aspects
Humans
Immunomagnetic Separation - methods
Immunopathology
Infant
Kawasaki disease
Male
Medical sciences
Microscopy, Confocal
Mucocutaneous Lymph Node Syndrome - blood
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Stem Cells - pathology
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Summary:summary Recent reports have demonstrated that circulating endothelial cells (CECs) are observed in several diseases with vascular injury. Because Kawasaki disease (KD) is one type of systemic vasculitis, we hypothesized that an increased number of CECs may be associated with the appearance of complicated coronary artery lesions (CAL). In the present study we investigated the enumeration and origin of CECs in 20 patients with KD, using an immunohistochemical method with monoclonal antibodies: clone P1H12 against ECs and clone AC133 against endothelial progenitor cells (EPCs), which were derived from the bone marrow. The mean number of CECs increased significantly (P 
ISSN:0009-9104
1365-2249
DOI:10.1046/j.1365-2249.2003.02091.x