Lymphoproliferative disease in antibody deficiency: a multi‐centre study

SUMMARY We have undertaken a retrospective study of antibody deficient patients, with and without lymphoma, and assessed the ability of specific polymerase chain reaction (PCR) primers to determine if the detection of clonal lymphocyte populations correlates with clinical and immunohistochemical dia...

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Bibliographic Details
Published in:Clinical and experimental immunology 2003-11, Vol.134 (2), p.314-320
Main Authors: GOMPELS, M. M., HODGES, E., LOCK, R. J., ANGUS, B., WHITE, H., LARKIN, A., CHAPEL, H. M., SPICKETT, G. P., MISBAH, S. A., SMITH, J. L.
Format: Article
Language:English
Subjects:
Adult
Age Distribution
Aged
antibody deficiency
Biological and medical sciences
Clinical Studies
Common Variable Immunodeficiency - complications
CVID
Epstein-Barr virus
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
immunodeficiency
Immunologic Deficiency Syndromes - complications
Immunopathology
lymphoma
Lymphoma - diagnosis
Lymphoma - etiology
Lymphoma, B-Cell - etiology
lymphoproliferative disorder
Male
Medical sciences
Middle Aged
Neoplastic Stem Cells - pathology
PCR
Polymerase Chain Reaction - methods
Retrospective Studies
Sex Distribution
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Summary:SUMMARY We have undertaken a retrospective study of antibody deficient patients, with and without lymphoma, and assessed the ability of specific polymerase chain reaction (PCR) primers to determine if the detection of clonal lymphocyte populations correlates with clinical and immunohistochemical diagnosis of lymphoma. We identified 158 cases with antibody deficiency presenting during the past 20 years. Paraffin‐embedded biopsy specimens or slides were available for analysis in a cohort of 34 patients. Of these patients, 29 had common variable immunodeficiency, one X‐linked agammaglobulinaemia, one X‐linked immunoglobulin deficiency of uncertain cause and three isolated IgG subclass deficiency. We have confirmed that lymphoma in antibody deficiency is predominantly B cell in origin. Clonal lymphocyte populations were demonstrated in biopsies irrespective of histology (16/19 with lymphoma and 11/15 without). Isolated evidence of clonality in biopsy material is therefore an insufficient diagnostic criterion to determine malignancy. Furthermore, our data suggest that clonal expansions are rarely the result of Epstein–Barr virus‐driven disease.
ISSN:0009-9104
1365-2249
DOI:10.1046/j.1365-2249.2003.02253.x