Pleiotropic effects of CXC chemokines in gastric carcinoma: differences in CXCL8 and CXCL1 expression between diffuse and intestinal types of gastric carcinoma

SUMMARY CXC chemokines modulate host immunity, neovascularization, growth and invasive behaviour of tumours. Despite their relevance in tumour biology, chemokine expression in intestinal‐ and diffuse‐type gastric carcinoma, which exhibit a completely different growth pattern, has not been investigat...

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Published in:Clinical and experimental immunology 2003-12, Vol.134 (3), p.508-515
Main Authors: ECK, M., SCHMAUßER, B., SCHELLER, K., BRÄNdlein, S., MÜLLER‐HERMELINK, H. K.
Format: Article
Language:English
Subjects:
Antigens, CD - analysis
Antigens, CD34 - analysis
Antigens, Differentiation, Myelomonocytic - analysis
Biological and medical sciences
Carcinoma - blood supply
Carcinoma - immunology
Carcinoma - pathology
CD3 Complex - analysis
Chemokine CXCL1
Chemokine CXCL10
Chemokine CXCL9
chemokine receptors
Chemokines, CXC - analysis
Clinical Studies
CXC chemokines
gastric carcinoma
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunohistochemistry - methods
Intercellular Signaling Peptides and Proteins - analysis
Interferon-gamma - analysis
Interleukin-8 - analysis
Lymphocytes, Tumor-Infiltrating - immunology
Medical sciences
Neovascularization, Pathologic
Regression Analysis
Stomach Neoplasms - blood supply
Stomach Neoplasms - immunology
Stomach Neoplasms - pathology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:SUMMARY CXC chemokines modulate host immunity, neovascularization, growth and invasive behaviour of tumours. Despite their relevance in tumour biology, chemokine expression in intestinal‐ and diffuse‐type gastric carcinoma, which exhibit a completely different growth pattern, has not been investigated in detail. In this study, expression of the CXC chemokines CXCL8 [interleukin (IL)‐8], CXCL1 [growth‐related oncogene alpha (Groα)], CXCL9 [monokine induced by interferon (IFN)‐γ] and CXCL10 [IFN‐γ‐inducible protein‐10 (IP‐10)] and the corresponding chemokine receptors CXCR1–3 was investigated by immunohistochemistry in intestinal‐ and diffuse‐type gastric carcinoma. Tumour cells of all patients expressed CXCL8. CXCL8 expression was significantly stronger in tumour cells of diffuse‐ rather than intestinal‐type gastric carcinoma (P 
ISSN:0009-9104
1365-2249
DOI:10.1111/j.1365-2249.2003.02305.x