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The candidate gene approach: have murine models informed the study of human SLE?
SUMMARY Genome wide linkage studies in human SLE have identified seven highly significant loci linked to SLE, and more than 20 other loci showing suggestive linkage to disease. However, pin‐pointing the susceptibility alleles in candidate genes within these linkage regions is challenging, due the ge...
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| Published in: | Clinical and experimental immunology 2004-07, Vol.137 (1), p.1-7 |
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| container_title | Clinical and experimental immunology |
| container_volume | 137 |
| creator | CUNNINGHAME GRAHAM, D. S. VYSE, T. J. |
| description | SUMMARY
Genome wide linkage studies in human SLE have identified seven highly significant loci linked to SLE, and more than 20 other loci showing suggestive linkage to disease. However, pin‐pointing the susceptibility alleles in candidate genes within these linkage regions is challenging, due the genetic heterogeneity, racial differences and environmental influences on disease aetiology. Utilization of murine models of spontaneous lupus nephritis provide a complementary approach, which may then identify candidate genes for analysis in human cases. This review highlights the utility of cross‐species approach to identify and characterize the effect of given candidate genes in lupus. The examples described in this review demonstrate the importance of bringing together both genetic and functional information in human and mouse studies. |
| doi_str_mv | 10.1111/j.1365-2249.2004.02525.x |
| format | article |
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Genome wide linkage studies in human SLE have identified seven highly significant loci linked to SLE, and more than 20 other loci showing suggestive linkage to disease. However, pin‐pointing the susceptibility alleles in candidate genes within these linkage regions is challenging, due the genetic heterogeneity, racial differences and environmental influences on disease aetiology. Utilization of murine models of spontaneous lupus nephritis provide a complementary approach, which may then identify candidate genes for analysis in human cases. This review highlights the utility of cross‐species approach to identify and characterize the effect of given candidate genes in lupus. The examples described in this review demonstrate the importance of bringing together both genetic and functional information in human and mouse studies.</description><identifier>ISSN: 0009-9104</identifier><identifier>EISSN: 1365-2249</identifier><identifier>DOI: 10.1111/j.1365-2249.2004.02525.x</identifier><identifier>PMID: 15196236</identifier><identifier>CODEN: CEXIAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Animals ; Autoimmunity - genetics ; Biological and medical sciences ; candidate gene ; Disease Models, Animal ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Genetic Heterogeneity ; Genetic Linkage - genetics ; Genetic Predisposition to Disease - genetics ; human SLE ; Humans ; Immunity, Innate - genetics ; Immunopathology ; Lupus Erythematosus, Systemic - genetics ; Lupus Erythematosus, Systemic - immunology ; Lupus Nephritis - genetics ; Lupus Nephritis - immunology ; Medical sciences ; Mice ; murine model ; Phenotype ; Receptors, IgG - genetics ; Review</subject><ispartof>Clinical and experimental immunology, 2004-07, Vol.137 (1), p.1-7</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Jul 2004</rights><rights>2004 Blackwell Publishing Ltd 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5275-62a56586607efe5a59b45386801320b73b31c7fa4eaed6a5dee493096dad36673</citedby><cites>FETCH-LOGICAL-c5275-62a56586607efe5a59b45386801320b73b31c7fa4eaed6a5dee493096dad36673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1809082/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1809082/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15877744$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15196236$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CUNNINGHAME GRAHAM, D. S.</creatorcontrib><creatorcontrib>VYSE, T. J.</creatorcontrib><title>The candidate gene approach: have murine models informed the study of human SLE?</title><title>Clinical and experimental immunology</title><addtitle>Clin Exp Immunol</addtitle><description>SUMMARY
Genome wide linkage studies in human SLE have identified seven highly significant loci linked to SLE, and more than 20 other loci showing suggestive linkage to disease. However, pin‐pointing the susceptibility alleles in candidate genes within these linkage regions is challenging, due the genetic heterogeneity, racial differences and environmental influences on disease aetiology. Utilization of murine models of spontaneous lupus nephritis provide a complementary approach, which may then identify candidate genes for analysis in human cases. This review highlights the utility of cross‐species approach to identify and characterize the effect of given candidate genes in lupus. The examples described in this review demonstrate the importance of bringing together both genetic and functional information in human and mouse studies.</description><subject>Animals</subject><subject>Autoimmunity - genetics</subject><subject>Biological and medical sciences</subject><subject>candidate gene</subject><subject>Disease Models, Animal</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Genetic Heterogeneity</subject><subject>Genetic Linkage - genetics</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>human SLE</subject><subject>Humans</subject><subject>Immunity, Innate - genetics</subject><subject>Immunopathology</subject><subject>Lupus Erythematosus, Systemic - genetics</subject><subject>Lupus Erythematosus, Systemic - immunology</subject><subject>Lupus Nephritis - genetics</subject><subject>Lupus Nephritis - immunology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>murine model</subject><subject>Phenotype</subject><subject>Receptors, IgG - genetics</subject><subject>Review</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqNkVtv1DAQhS0EokvhLyALCd4SfIntBAkQWi200kogUZ6t2WTSZJXEi52U7r-v01319oRffJlvjs74EEI5S3lcH7cpl1olQmRFKhjLUiaUUOn1M7K4KzwnC8ZYkRScZSfkVQjbeNVai5fkhCteaCH1gvy6aJCWMFRtBSPSSxyQwm7nHZTNJ9rAFdJ-8m187V2FXaDtUDvfY0XH2BjGqdpTV9Nm6mGgv9err6_Jixq6gG-O-yn58311sTxL1j9_nC-_rZNSCaMSLUBplWvNDNaoQBWbTMlc54xLwTZGbiQvTQ0ZAlYaVIWYFZIVuoJKam3kKfly0N1Nm2inxGH00Nmdb3vwe-ugtY8rQ9vYS3dlec4Kloso8OEo4N3fCcNo-zaU2HUwoJuCNYIJrqWM4Lsn4NZNfojD2fiLea6NKiKUH6DSuxA81ndOOLNzZnZr52jsHI2dM7O3mdnr2Pr24ST3jceQIvD-CEAooas9DGUbHnC5MSbLIvf5wP1rO9z_twG7XJ3PJ3kDVCuxVA</recordid><startdate>200407</startdate><enddate>200407</enddate><creator>CUNNINGHAME GRAHAM, D. S.</creator><creator>VYSE, T. J.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Oxford University Press</general><general>Blackwell Science Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200407</creationdate><title>The candidate gene approach: have murine models informed the study of human SLE?</title><author>CUNNINGHAME GRAHAM, D. S. ; VYSE, T. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5275-62a56586607efe5a59b45386801320b73b31c7fa4eaed6a5dee493096dad36673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Autoimmunity - genetics</topic><topic>Biological and medical sciences</topic><topic>candidate gene</topic><topic>Disease Models, Animal</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Genetic Heterogeneity</topic><topic>Genetic Linkage - genetics</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>human SLE</topic><topic>Humans</topic><topic>Immunity, Innate - genetics</topic><topic>Immunopathology</topic><topic>Lupus Erythematosus, Systemic - genetics</topic><topic>Lupus Erythematosus, Systemic - immunology</topic><topic>Lupus Nephritis - genetics</topic><topic>Lupus Nephritis - immunology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>murine model</topic><topic>Phenotype</topic><topic>Receptors, IgG - genetics</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CUNNINGHAME GRAHAM, D. S.</creatorcontrib><creatorcontrib>VYSE, T. J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CUNNINGHAME GRAHAM, D. S.</au><au>VYSE, T. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The candidate gene approach: have murine models informed the study of human SLE?</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>2004-07</date><risdate>2004</risdate><volume>137</volume><issue>1</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><coden>CEXIAL</coden><abstract>SUMMARY
Genome wide linkage studies in human SLE have identified seven highly significant loci linked to SLE, and more than 20 other loci showing suggestive linkage to disease. However, pin‐pointing the susceptibility alleles in candidate genes within these linkage regions is challenging, due the genetic heterogeneity, racial differences and environmental influences on disease aetiology. Utilization of murine models of spontaneous lupus nephritis provide a complementary approach, which may then identify candidate genes for analysis in human cases. This review highlights the utility of cross‐species approach to identify and characterize the effect of given candidate genes in lupus. The examples described in this review demonstrate the importance of bringing together both genetic and functional information in human and mouse studies.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15196236</pmid><doi>10.1111/j.1365-2249.2004.02525.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical and experimental immunology, 2004-07, Vol.137 (1), p.1-7 |
| issn | 0009-9104 1365-2249 |
| language | eng |
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| source | Open Access: PubMed Central |
| subjects | Animals Autoimmunity - genetics Biological and medical sciences candidate gene Disease Models, Animal Fundamental and applied biological sciences. Psychology Fundamental immunology Genetic Heterogeneity Genetic Linkage - genetics Genetic Predisposition to Disease - genetics human SLE Humans Immunity, Innate - genetics Immunopathology Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Lupus Nephritis - genetics Lupus Nephritis - immunology Medical sciences Mice murine model Phenotype Receptors, IgG - genetics Review |
| title | The candidate gene approach: have murine models informed the study of human SLE? |
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