Immunological profile of peripheral blood lymphocytes and monocytes/macrophages in Kawasaki disease

Summary Kawasaki disease (KD) is an acute illness of early childhood characterized by prolonged fever, diffuse mucosal inflammation, indurative oedema of the hands and feet, a polymorphous skin rash and nonsuppurative lymphadenopathy. The histopathological findings in KD comprise panvasculitis with...

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Bibliographic Details
Published in:Clinical and experimental immunology 2005-09, Vol.141 (3), p.381-387
Main Authors: Matsubara, T., Ichiyama, T., Furukawa, S.
Format: Article
Language:English
Subjects:
Acute Disease
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunoglobulins, Intravenous
Immunopathology
Infant
intravenous immnoglobulin
Kawasaki disease
Leukocyte Count
Lymphocyte Activation
Lymphocyte Subsets
Lymphocytes - immunology
Macrophage Activation
Macrophages - immunology
Medical sciences
monocytes/macrophages
Mucocutaneous Lymph Node Syndrome - immunology
Mucocutaneous Lymph Node Syndrome - therapy
peripheral blood
Reviews
T lymphocytes
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Summary:Summary Kawasaki disease (KD) is an acute illness of early childhood characterized by prolonged fever, diffuse mucosal inflammation, indurative oedema of the hands and feet, a polymorphous skin rash and nonsuppurative lymphadenopathy. The histopathological findings in KD comprise panvasculitis with endothelial necrosis, and the infiltration of mononuclear cells into small and medium‐sized blood vessels. The levels of many proinflammatory cytokines, chemokines and adhesion molecules can be elevated in sera from children with KD at the acute stage. Although many immunological studies on KD involving peripheral blood have been reported, the data obtained remain controversial. This review focuses on the immune response of peripheral blood lymphocytes and monocytes/macrophages during acute KD.
ISSN:0009-9104
1365-2249
DOI:10.1111/j.1365-2249.2005.02821.x