Translational Mini-Review Series on Toll-like Receptors: Networks regulated by Toll-like receptors mediate innate and adaptive immunity

The Toll-like receptor (TLR) family provide key components of mammalian immunity and are part of the earliest surveillance mechanisms responding to infection. Their activation triggers the innate immune response, and is crucial to the successful induction of Th1/Th2-phenotyped adaptive immunity. Inn...

Full description

Saved in:
Bibliographic Details
Published in:Clinical and experimental immunology 2007-02, Vol.147 (2), p.199-207
Main Authors: Parker, L.C, Prince, L.R, Sabroe, I
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Fundamental immunology
immunity
Immunity, Cellular
Immunity, Innate
Immunopathology
inflammation
Inflammation - immunology
innate immunity
Medical sciences
Signal Transduction - immunology
TLR
Toll-Like Receptors - immunology
Translational Mini-Review Series on TLRs
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The Toll-like receptor (TLR) family provide key components of mammalian immunity and are part of the earliest surveillance mechanisms responding to infection. Their activation triggers the innate immune response, and is crucial to the successful induction of Th1/Th2-phenotyped adaptive immunity. Innate immunity was long considered to be non-specific and somewhat simple compared to adaptive immunity, mediated via the engulfment and lysis of microbial pathogens by phagocytic cells such as macrophages and neutrophils, and involving no complex protein-protein interactions. The emergence of the TLR field has contributed to a revision of our understanding, and innate immunity is now viewed as a highly complex process, in line with adaptive immunity. This review will give a brief overview of our current knowledge of TLR biology, and will focus on TLRs as key components in complex networks that activate, integrate and select the appropriate innate and adaptive immune responses in the face of immunological danger.
ISSN:0009-9104
1365-2249
DOI:10.1111/j.1365-2249.2006.03203.x