Role of respiratory syncytial virus in acute otitis media: Implications for vaccine development

Abstract We summarize herein the results of various virologic studies of acute otitis media (AOM) conducted at our site over a 10-year period. Among 566 children with AOM, respiratory syncytial virus (RSV) was the most common virus identified in either middle ear fluid or nasal wash; it was found in...

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Bibliographic Details
Published in:Vaccine 2007-02, Vol.25 (9), p.1683-1689
Main Authors: Patel, Janak A, Nguyen, Dang T, Revai, Krystal, Chonmaitree, Tasnee
Format: Article
Language:English
Subjects:
Acute Disease
Adenoviruses
Allergy and Immunology
Antibiotics
Antigens
Applied microbiology
Bacteria
Biological and medical sciences
Child
Child, Preschool
Ear diseases
Female
Fundamental and applied biological sciences. Psychology
Humans
Immunization
Infant
Male
Microbiology
Miscellaneous
Otitis media
Otitis Media - diagnosis
Otitis Media - epidemiology
Otitis Media - prevention & control
Otitis Media - virology
Prevalence
Respiratory syncytial virus
Respiratory Syncytial Virus Infections - epidemiology
Respiratory Syncytial Virus Infections - prevention & control
Respiratory Syncytial Virus Infections - virology
Respiratory Syncytial Virus Vaccines
Respiratory Syncytial Virus, Human - immunology
Respiratory Syncytial Virus, Human - isolation & purification
Respiratory tract
Streptococcus infections
Studies
Vaccine
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Viral infections
Virology
Viruses
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Summary:Abstract We summarize herein the results of various virologic studies of acute otitis media (AOM) conducted at our site over a 10-year period. Among 566 children with AOM, respiratory syncytial virus (RSV) was the most common virus identified in either middle ear fluid or nasal wash; it was found in 16% of all children and 38% of virus-positive children. Seventy-one percent of the children with RSV were 1 year of age or older, which was significantly older than all other viruses combined ( P = 0.045). RSV infection was associated with the common bacterial pathogens causing AOM. Past efforts to develop vaccines for RSV have emphasized prevention of lower respiratory tract infection in infants, which is a more serious problem but less common than AOM. Our results suggest that RSV vaccines that work only against infection in older children may have value in preventing AOM, the most common pediatric disease.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2006.10.045