Recent human effective population size estimated from linkage disequilibrium

Effective population size (N(e)) determines the amount of genetic variation, genetic drift, and linkage disequilibrium (LD) in populations. Here, we present the first genome-wide estimates of human effective population size from LD data. Chromosome-specific effective population size was estimated fo...

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Bibliographic Details
Published in:Genome Research 2007-04, Vol.17 (4), p.520-526
Main Authors: Tenesa, Albert, Navarro, Pau, Hayes, Ben J, Duffy, David L, Clarke, Geraldine M, Goddard, Mike E, Visscher, Peter M
Format: Article
Language:English
Subjects:
Algorithms
Female
Gene Frequency
Genetics, Population - methods
Genome, Human
Haplotypes
Humans
Linkage Disequilibrium
Male
Methods
Models, Genetic
Polymorphism, Single Nucleotide - genetics
Population Density
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Summary:Effective population size (N(e)) determines the amount of genetic variation, genetic drift, and linkage disequilibrium (LD) in populations. Here, we present the first genome-wide estimates of human effective population size from LD data. Chromosome-specific effective population size was estimated for all autosomes and the X chromosome from estimated LD between SNP pairs
ISSN:1088-9051
1549-5469
1549-5477
DOI:10.1101/gr.6023607