Isoflurane compared with midazolam for sedation in the intensive care unit

OBJECTIVE--To compare isoflurane with midazolam for sedation of ventilated patients. DESIGN--Randomised control study. Setting--Intensive care unit in university teaching hospital. PATIENTS--Sixty patients aged 18-76 who required mechanical ventilation. INTERVENTIONS--Sedation with either 0.1-0.6% i...

Full description

Saved in:
Bibliographic Details
Published in:BMJ 1989-05, Vol.298 (6683), p.1277-1280
Main Authors: Kong, K. L., Willatts, S. M., Prys-Roberts, C.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Analgesia
Anesthesia
Artificial respiration
Blood Pressure - drug effects
Clinical Trials as Topic
Critical Care
Female
Heart Rate - drug effects
Humans
Hypnotics and Sedatives
Intensive care
Intensive Care Units
Intravenous administration
Isoflurane
Isoflurane - pharmacology
Male
Mechanical ventilation
Midazolam
Midazolam - pharmacology
Middle Aged
Morphine
Random Allocation
Respiration, Artificial
Sedatives
Statistical median
Time Factors
Ventilation systems
Ventilator Weaning
Weaning
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:OBJECTIVE--To compare isoflurane with midazolam for sedation of ventilated patients. DESIGN--Randomised control study. Setting--Intensive care unit in university teaching hospital. PATIENTS--Sixty patients aged 18-76 who required mechanical ventilation. INTERVENTIONS--Sedation with either 0.1-0.6% isoflurane in an air-oxygen mixture (30 patients) or a continuous intravenous infusion of midazolam 0.01-0.20 mg/kg/h (30 patients). Sedation was assessed initially and hourly thereafter on a six point scale. Incremental intravenous doses of morphine 0.05 mg/kg were given for analgesia as required. The trial sedative was stopped when the patient was judged ready for weaning from ventilatory support or at 24 hours (whichever was earlier). END POINT--Achievement of a predetermined level of sedation for as much of the time as possible. MAIN RESULTS--Isoflurane produced satisfactory sedation for a greater proportion of time (86%) than midazolam (64%), and patients sedated with isoflurane recovered more rapidly from sedation. CONCLUSION--Isoflurane is a promising alternative technique for sedation of ventilated patients in the intensive care unit.
ISSN:0959-8138
1468-5833
1756-1833
DOI:10.1136/bmj.298.6683.1277