The effect of Paf antagonists on bronchial hyperresponsiveness induced by Paf, propranolol or indomethacin

1 Intravenous administration of platelet activating factor, Paf (600 ng kg−1 h−1) to ventilated anaesthetised guinea‐pigs induced bronchial hyperresponsiveness to i.v. acetylcholine. 2 Pretreatment of ventilated, anaesthetised guinea‐pigs with the β‐adrenoceptor antagonist, propranolol, or the non‐s...

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Bibliographic Details
Published in:British journal of pharmacology 1989-07, Vol.97 (3), p.717-722
Main Authors: Dixon, E.J.A., Wilsoncroft, P., Robertson, D.N., Page, C.P.
Format: Article
Language:English
Subjects:
Acetylcholine - pharmacology
Animals
Azepines - pharmacology
Biological and medical sciences
Bronchi - drug effects
Diterpenes
Drug toxicity and drugs side effects treatment
Ginkgolides
Guinea Pigs
Histamine - pharmacology
In Vitro Techniques
indomethacin
Indomethacin - pharmacology
Lactones - pharmacology
Male
Medical sciences
Pharmacology. Drug treatments
Phospholipid Ethers - pharmacology
Platelet Activating Factor - antagonists & inhibitors
Platelet Activating Factor - pharmacology
platelet-activating factor
propranolol
Propranolol - pharmacology
Respiratory Hypersensitivity - physiopathology
Toxicity: respiratory system, ent, stomatology
Triazines - pharmacology
Triazoles
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Summary:1 Intravenous administration of platelet activating factor, Paf (600 ng kg−1 h−1) to ventilated anaesthetised guinea‐pigs induced bronchial hyperresponsiveness to i.v. acetylcholine. 2 Pretreatment of ventilated, anaesthetised guinea‐pigs with the β‐adrenoceptor antagonist, propranolol, or the non‐steroidal anti‐inflammatory drug, indomethacin, induced bronchial hyperresponsiveness to i.v. histamine. 3 Paf‐induced bronchial hyperresponsiveness was significantly attenuated by pretreatment with three different Paf antagonists, CV‐3988, BN 52021 and WEB 2086. 4 Pretreatment of guinea‐pigs with CV‐3988, BN 52021 or WEB 2086 at doses inhibiting Paf‐induced bronchial hyperresponsiveness, had no significant effect on propranolol or indomethacin‐induced bronchial hyperresponsiveness. 5 It is suggested that bronchial hyperresponsiveness induced by propranolol or indomethacin is not secondary to Paf release in the guinea‐pig.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1989.tb12008.x