Dual effects of 5‐hydroxytryptamine on the release of γ‐aminobutyric acid from myenteric neurones of the guinea‐pig ileum

The effects of 5‐hydroxytryptamine (5‐HT) on the release of γ‐aminobutyric acid (GABA) were examined in the longitudinal muscle‐myenteric plexus (LM‐MP) preparation of guinea‐pig ileum. 5‐HT increased the spontaneous release and inhibited the electrically‐evoked release of [3H]‐GABA. The 5‐HT‐evoked...

Full description

Saved in:
Bibliographic Details
Published in:British journal of pharmacology 1989-10, Vol.98 (2), p.339-341
Main Authors: Shirakawa, Junji, Takeda, Koichiro, Taniyama, Kohtaro, Tanaka, Chikako
Format: Article
Language:English
Subjects:
Animals
Electric Stimulation
gamma-Aminobutyric Acid - metabolism
Guinea Pigs
Ileum - innervation
Ileum - metabolism
In Vitro Techniques
Male
Myenteric Plexus - cytology
Myenteric Plexus - metabolism
Neurons - metabolism
Serotonin - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effects of 5‐hydroxytryptamine (5‐HT) on the release of γ‐aminobutyric acid (GABA) were examined in the longitudinal muscle‐myenteric plexus (LM‐MP) preparation of guinea‐pig ileum. 5‐HT increased the spontaneous release and inhibited the electrically‐evoked release of [3H]‐GABA. The 5‐HT‐evoked release was Ca2+‐dependent and tetrodotoxin‐sensitive, and was antagonized by (3α‐tropanyl)‐1H‐indole‐3‐carboxylic acid ester (ICS 205–930), but not by methysergide and ketanserin. The inhibitory effect of 5‐HT was antagonized by methysergide, but not by ketanserin and ICS 205–930. 8‐Hydroxy‐2‐(di‐n‐propylamino)tetralin mimicked the inhibitory effect of 5‐HT. Thus, 5‐HT may exert an excitatory effect on the enteric GABAergic neurone via the 5‐HT3 receptor and an inhibitory effect via the 5‐HT1A receptor.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1989.tb12601.x