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The effect of adrenalectomy on interleukin‐1 release in vitro and in vivo
1 Peritoneal macrophages (Mø) collected from adrenalectomized (ADX) rats released more interleukin‐1 (IL‐1) activity and prostaglandin E2 (PGE2) than macrophages from sham‐operated (SHO) rats. 2 The increase in IL‐1 activity in the supernatants was confirmed by the increase of the cell‐associated 33...
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| Published in: | British journal of pharmacology 1989-12, Vol.98 (4), p.1137-1142 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c4537-e5ee68ffbbcba58dc7850504d060d0a08f0121c792083dc61859385a3af11b533 |
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| cites | cdi_FETCH-LOGICAL-c4537-e5ee68ffbbcba58dc7850504d060d0a08f0121c792083dc61859385a3af11b533 |
| container_end_page | 1142 |
| container_issue | 4 |
| container_start_page | 1137 |
| container_title | British journal of pharmacology |
| container_volume | 98 |
| creator | Perretti, Mauro Becherucci, Cristina Scapigliati, Giuseppe Parente, Luca |
| description | 1
Peritoneal macrophages (Mø) collected from adrenalectomized (ADX) rats released more interleukin‐1 (IL‐1) activity and prostaglandin E2 (PGE2) than macrophages from sham‐operated (SHO) rats.
2
The increase in IL‐1 activity in the supernatants was confirmed by the increase of the cell‐associated 33 kD IL‐1α precursor in ADX macrophages stimulated by lipopolysaccharide (LPS).
3
After the injection of Complete Freund's Adjuvant (CFA) to induce adjuvant arthritis, 60% of the ADX rats died, while no deaths occurred in the SHO group.
4
The in vivo administration of dexamethasone inhibited both IL‐1 and PGE2 release by macrophages as well as protecting ADX animals from CFA‐induced death. Indomethacin and BW 755C partially protected the animals from this lethal effect.
5
These results suggest that adrenalectomy induces an increased release of IL‐1 both in vitro and in vivo, and are consistent with a feedback mechanism between IL‐1 and glucocorticoid hormones. |
| doi_str_mv | 10.1111/j.1476-5381.1989.tb12657.x |
| format | article |
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Peritoneal macrophages (Mø) collected from adrenalectomized (ADX) rats released more interleukin‐1 (IL‐1) activity and prostaglandin E2 (PGE2) than macrophages from sham‐operated (SHO) rats.
2
The increase in IL‐1 activity in the supernatants was confirmed by the increase of the cell‐associated 33 kD IL‐1α precursor in ADX macrophages stimulated by lipopolysaccharide (LPS).
3
After the injection of Complete Freund's Adjuvant (CFA) to induce adjuvant arthritis, 60% of the ADX rats died, while no deaths occurred in the SHO group.
4
The in vivo administration of dexamethasone inhibited both IL‐1 and PGE2 release by macrophages as well as protecting ADX animals from CFA‐induced death. Indomethacin and BW 755C partially protected the animals from this lethal effect.
5
These results suggest that adrenalectomy induces an increased release of IL‐1 both in vitro and in vivo, and are consistent with a feedback mechanism between IL‐1 and glucocorticoid hormones.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/j.1476-5381.1989.tb12657.x</identifier><identifier>PMID: 2514946</identifier><identifier>CODEN: BJPCBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine - pharmacology ; Adrenalectomy ; Adrenals. Interrenals ; Adrenomedullary hormones. Regulation ; Animals ; Biological and medical sciences ; Cells, Cultured ; Dexamethasone - pharmacology ; Dinoprostone - metabolism ; Freund's Adjuvant - pharmacology ; Fundamental and applied biological sciences. Psychology ; Humans ; In Vitro Techniques ; Indomethacin - pharmacology ; Interleukin-1 - metabolism ; Lipopolysaccharides - pharmacology ; Macrophages - drug effects ; Macrophages - metabolism ; Precipitin Tests ; Rats ; Rats, Inbred Strains ; Vertebrates: endocrinology</subject><ispartof>British journal of pharmacology, 1989-12, Vol.98 (4), p.1137-1142</ispartof><rights>1989 British Pharmacological Society</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4537-e5ee68ffbbcba58dc7850504d060d0a08f0121c792083dc61859385a3af11b533</citedby><cites>FETCH-LOGICAL-c4537-e5ee68ffbbcba58dc7850504d060d0a08f0121c792083dc61859385a3af11b533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1854829/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1854829/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6715286$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2514946$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perretti, Mauro</creatorcontrib><creatorcontrib>Becherucci, Cristina</creatorcontrib><creatorcontrib>Scapigliati, Giuseppe</creatorcontrib><creatorcontrib>Parente, Luca</creatorcontrib><title>The effect of adrenalectomy on interleukin‐1 release in vitro and in vivo</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>1
Peritoneal macrophages (Mø) collected from adrenalectomized (ADX) rats released more interleukin‐1 (IL‐1) activity and prostaglandin E2 (PGE2) than macrophages from sham‐operated (SHO) rats.
2
The increase in IL‐1 activity in the supernatants was confirmed by the increase of the cell‐associated 33 kD IL‐1α precursor in ADX macrophages stimulated by lipopolysaccharide (LPS).
3
After the injection of Complete Freund's Adjuvant (CFA) to induce adjuvant arthritis, 60% of the ADX rats died, while no deaths occurred in the SHO group.
4
The in vivo administration of dexamethasone inhibited both IL‐1 and PGE2 release by macrophages as well as protecting ADX animals from CFA‐induced death. Indomethacin and BW 755C partially protected the animals from this lethal effect.
5
These results suggest that adrenalectomy induces an increased release of IL‐1 both in vitro and in vivo, and are consistent with a feedback mechanism between IL‐1 and glucocorticoid hormones.</description><subject>4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine - pharmacology</subject><subject>Adrenalectomy</subject><subject>Adrenals. Interrenals</subject><subject>Adrenomedullary hormones. Regulation</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Dexamethasone - pharmacology</subject><subject>Dinoprostone - metabolism</subject><subject>Freund's Adjuvant - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Indomethacin - pharmacology</subject><subject>Interleukin-1 - metabolism</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - metabolism</subject><subject>Precipitin Tests</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Vertebrates: endocrinology</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><recordid>eNqVkcFu1DAQhi0EKkvhEZAihLgleOI4djggoAKKqASHcrYcZ0yzeO1iZ5fujUfgGXkSHDZawQnhiz3-v_k1o5-QR0AryOfpuoJGtCVnEiroZFdNPdQtF9XNLbI6SrfJilIqSgAp75J7Ka0pzaLgJ-Sk5tB0Tbsi7y-vsEBr0UxFsIUeInrtchU2-yL4YvQTRofbL6P_-f0HFBEd6oT5v9iNUwyF9sOh2IX75I7VLuGD5T4ln968vjw7Ly8-vH139vKiNA1nokSO2Epr-970msvBCMkpp81AWzpQTaWlUIMRXU0lG0wLkndMcs20Beg5Y6fk-cH3ettvcDDop6iduo7jRse9CnpUfyt-vFKfw05lp0bWXTZ4shjE8HWLaVKbMRl0TnsM26RE17C6pvSfIGS_RkiRwWcH0MSQUkR7nAaomjNTazUHo-Zg1JyZWjJTN7n54Z_7HFuXkLL-eNF1MtrZqL0Z0xFrBfBaztiLA_ZtdLj_jwHUq4_nv5_sF71FtV4</recordid><startdate>198912</startdate><enddate>198912</enddate><creator>Perretti, Mauro</creator><creator>Becherucci, Cristina</creator><creator>Scapigliati, Giuseppe</creator><creator>Parente, Luca</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>198912</creationdate><title>The effect of adrenalectomy on interleukin‐1 release in vitro and in vivo</title><author>Perretti, Mauro ; Becherucci, Cristina ; Scapigliati, Giuseppe ; Parente, Luca</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4537-e5ee68ffbbcba58dc7850504d060d0a08f0121c792083dc61859385a3af11b533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine - pharmacology</topic><topic>Adrenalectomy</topic><topic>Adrenals. Interrenals</topic><topic>Adrenomedullary hormones. Regulation</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Dexamethasone - pharmacology</topic><topic>Dinoprostone - metabolism</topic><topic>Freund's Adjuvant - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Indomethacin - pharmacology</topic><topic>Interleukin-1 - metabolism</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - metabolism</topic><topic>Precipitin Tests</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perretti, Mauro</creatorcontrib><creatorcontrib>Becherucci, Cristina</creatorcontrib><creatorcontrib>Scapigliati, Giuseppe</creatorcontrib><creatorcontrib>Parente, Luca</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perretti, Mauro</au><au>Becherucci, Cristina</au><au>Scapigliati, Giuseppe</au><au>Parente, Luca</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of adrenalectomy on interleukin‐1 release in vitro and in vivo</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1989-12</date><risdate>1989</risdate><volume>98</volume><issue>4</issue><spage>1137</spage><epage>1142</epage><pages>1137-1142</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><coden>BJPCBM</coden><abstract>1
Peritoneal macrophages (Mø) collected from adrenalectomized (ADX) rats released more interleukin‐1 (IL‐1) activity and prostaglandin E2 (PGE2) than macrophages from sham‐operated (SHO) rats.
2
The increase in IL‐1 activity in the supernatants was confirmed by the increase of the cell‐associated 33 kD IL‐1α precursor in ADX macrophages stimulated by lipopolysaccharide (LPS).
3
After the injection of Complete Freund's Adjuvant (CFA) to induce adjuvant arthritis, 60% of the ADX rats died, while no deaths occurred in the SHO group.
4
The in vivo administration of dexamethasone inhibited both IL‐1 and PGE2 release by macrophages as well as protecting ADX animals from CFA‐induced death. Indomethacin and BW 755C partially protected the animals from this lethal effect.
5
These results suggest that adrenalectomy induces an increased release of IL‐1 both in vitro and in vivo, and are consistent with a feedback mechanism between IL‐1 and glucocorticoid hormones.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2514946</pmid><doi>10.1111/j.1476-5381.1989.tb12657.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of pharmacology, 1989-12, Vol.98 (4), p.1137-1142 |
| issn | 0007-1188 1476-5381 |
| language | eng |
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| source | PubMed |
| subjects | 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine - pharmacology Adrenalectomy Adrenals. Interrenals Adrenomedullary hormones. Regulation Animals Biological and medical sciences Cells, Cultured Dexamethasone - pharmacology Dinoprostone - metabolism Freund's Adjuvant - pharmacology Fundamental and applied biological sciences. Psychology Humans In Vitro Techniques Indomethacin - pharmacology Interleukin-1 - metabolism Lipopolysaccharides - pharmacology Macrophages - drug effects Macrophages - metabolism Precipitin Tests Rats Rats, Inbred Strains Vertebrates: endocrinology |
| title | The effect of adrenalectomy on interleukin‐1 release in vitro and in vivo |
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