Mechanisms of epithelial dysfunction in giardiasis

ELECTROLYTE TRANSPORT ABNORMALITIES Previous studies using models in vivo and in vitro have established that Giardia causes malabsorption of glucose, sodium and water, and reduced disaccharidase activity, due to loss of epithelial absorptive surface area. 1, 3, 4, 11- 13 Observations from humans inf...

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Bibliographic Details
Published in:Gut 2007-03, Vol.56 (3), p.316-317
Main Author: Buret, Andre G
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Commentaries
Disease
Enterocytes - pathology
Genomes
Giardia - pathogenicity
Giardiasis - physiopathology
Hogs
Humans
Infections
Intestinal Diseases, Parasitic - physiopathology
Intestinal Mucosa - physiopathology
Lymphocytes
Malabsorption Syndromes - parasitology
Parasites
Permeability
Studies
Virulence
Citations: Items that cite this one
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Summary:ELECTROLYTE TRANSPORT ABNORMALITIES Previous studies using models in vivo and in vitro have established that Giardia causes malabsorption of glucose, sodium and water, and reduced disaccharidase activity, due to loss of epithelial absorptive surface area. 1, 3, 4, 11- 13 Observations from humans infected with this parasite now confirm these findings. 10 Recent reports have suggested that this parasite may also alter chloride secretory responses in human colonic cells in vitro, as well as in murine models. 14, 15 The findings of Troeger et al 10 show for the first time that, in addition to malabsorption, chronic giardiasis may cause hypersecretion of chloride in humans. [...]a combination of malabsorption and secretion of electrolytes seems to be responsible for fluid accumulation in the intestinal lumen during this infection.
ISSN:0017-5749
1468-3288
DOI:10.1136/gut.2006.107771