Improvement of the efficacy of influenza vaccination (H5N1) in chicken by using extract of Cochinchina momordica seed (ECMS)

Seeds of a Chinese traditional medicine plant, Cochinchina momordica were used in the present study for the improvement of influenza vaccine (H5N1) in chicken. Crude extraction from Cochinchina momordica seed (ECMS) was obtained by ethanol extraction method. In experiment No. 1, two weeks old chicke...

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Bibliographic Details
Published in:Journal of Zhejiang University. B. Science 2007-05, Vol.8 (5), p.331-337
Main Authors: Rajput, Zahid Iqbal, Xiao, Chen-wen, Hu, Song-hua, Arijo, Abdullah G, Soomro, Noor Mohammad
Format: Article
Language:English
Subjects:
Adjuvants
Agriculture - methods
Animal Sciences
Animals
Avian flu
Chickens
Drug Combinations
Drug Synergism
Drugs, Chinese Herbal - administration & dosage
Influenza
Influenza A Virus, H5N1 Subtype - drug effects
Influenza in Birds - prevention & control
Influenza Vaccines - administration & dosage
Magnoliopsida - chemistry
Momordica
Poultry
Poultry Diseases - prevention & control
Seeds - chemistry
Treatment Outcome
Vaccination - methods
Vaccines
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Summary:Seeds of a Chinese traditional medicine plant, Cochinchina momordica were used in the present study for the improvement of influenza vaccine (H5N1) in chicken. Crude extraction from Cochinchina momordica seed (ECMS) was obtained by ethanol extraction method. In experiment No. 1, two weeks old chickens were immunized with influenza vaccine (H5N1) alone or combined with ECMS (5, 10, 20, 40 and 80 microg/dose). Serum IgG antibody levels (by ELISA) as well as effects on daily weight gain were measured on 0, 7, 14 and 28th day after immunization. Results revealed that all ECMS groups numerically increased the antibody levels while 10 and 20 microg/dose groups significantly (P
ISSN:1673-1581
1862-1783
DOI:10.1631/jzus.2007.B0331