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Elevated CD4+/CD25+ T cell frequency and function during acute hepatitis C presage chronic evolution
Table 1 Patient characteristics Parameter HCV-T0 HCV-T6 HAV HD Age (y) (mean (SD)) 42 (3) 40 (2) 32 (5) 35 (6) Sex (M/F) 10/6 12/12 11/4 7/3 ALT level (U/l
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| Published in: | Gut 2006-09, Vol.55 (9), p.1370-1371 |
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| creator | Perrella, A Vitiello, L Atripaldi, L Conti, P Sbreglia, C Altamura, S Patarino, T Vela, R Morelli, G Bellopede, P Alone, C Racioppi, L Perrella, O |
| description | Table 1 Patient characteristics Parameter HCV-T0 HCV-T6 HAV HD Age (y) (mean (SD)) 42 (3) 40 (2) 32 (5) 35 (6) Sex (M/F) 10/6 12/12 11/4 7/3 ALT level (U/l |
| doi_str_mv | 10.1136/gut.2006.099887 |
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[dagger]Total count number (cells/mm3; values are mean (SD)). [double dagger]Percentage.</description><identifier>ISSN: 0017-5749</identifier><identifier>EISSN: 1468-3288</identifier><identifier>DOI: 10.1136/gut.2006.099887</identifier><identifier>PMID: 16905711</identifier><identifier>CODEN: GUTTAK</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and British Society of Gastroenterology</publisher><subject>Acute Disease ; acute hepatitis ; Adult ; CD4+/CD25 ; CD4-Positive T-Lymphocytes - immunology ; Disease Progression ; Female ; Genotype & phenotype ; Hepatitis ; Hepatitis C - immunology ; hepatitis C virus ; Hepatitis C, Chronic - immunology ; Humans ; Infections ; Interferon ; Letters ; Liver ; Lymphocytes ; Male ; Middle Aged ; Prognosis ; Receptors, Interleukin-2 - analysis ; Studies ; T regulatory lymphocytes ; T-Lymphocyte Subsets - immunology</subject><ispartof>Gut, 2006-09, Vol.55 (9), p.1370-1371</ispartof><rights>Copyright 2006 by Gut</rights><rights>Copyright: 2006 Copyright 2006 by Gut</rights><rights>Copyright © 2006 BMJ Publishing Group & British Society of Gastroenterology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b492t-37a8c3d7ed8e4dfdf80db9affe32697c068717fdaa8f0d9bfe23e6a9940f289f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860041/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860041/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16905711$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perrella, A</creatorcontrib><creatorcontrib>Vitiello, L</creatorcontrib><creatorcontrib>Atripaldi, L</creatorcontrib><creatorcontrib>Conti, P</creatorcontrib><creatorcontrib>Sbreglia, C</creatorcontrib><creatorcontrib>Altamura, S</creatorcontrib><creatorcontrib>Patarino, T</creatorcontrib><creatorcontrib>Vela, R</creatorcontrib><creatorcontrib>Morelli, G</creatorcontrib><creatorcontrib>Bellopede, P</creatorcontrib><creatorcontrib>Alone, C</creatorcontrib><creatorcontrib>Racioppi, L</creatorcontrib><creatorcontrib>Perrella, O</creatorcontrib><title>Elevated CD4+/CD25+ T cell frequency and function during acute hepatitis C presage chronic evolution</title><title>Gut</title><addtitle>Gut</addtitle><description>Table 1 Patient characteristics Parameter HCV-T0 HCV-T6 HAV HD Age (y) (mean (SD)) 42 (3) 40 (2) 32 (5) 35 (6) Sex (M/F) 10/6 12/12 11/4 7/3 ALT level (U/l <40) 1425 (539) 100 (50) 1418 (543) <40 AST level (U/l <40) 892 (305) 84 (24) 851 (221) <40 HCV-RNA (IU/ml (mean (SD)) 310 (232)x103 Positive na na Genotype 1a/1b 12/16 11/12 0 Non-1 4/16 1/12 Mode of infection Needlestick 1/16 0 Surgery procedure 2/16 0 Alimentary 0 15/15 Unclear 13/16 0 Immunological parameters CD3+ CD4+ 956 (297)[dagger]** 892 (103) 725 (200)** 772 (297)** CD3+ CD4+ CD25+ 130 (50)[dagger]** 111 (12) 46 (26)** 46 (13)** CD3+ CD4+ CD25+ 13.5 (3)[double dagger]** 11.2 (2) 6.3 (1)** 6 (1)** T regulatory functional assay¶ Ratio 1:2¶ 100§** 92 80 79 Ratio 1:20 99** 85** 70 55 HCV-T0, patients with hepatitis C virus at time 0; HCV-T6, patients hepatitis C virus after six months; HAV, patients with acute hepatitis A; HD, healthy donors; na, not applicable; ALT, alanine aminotransferase; AST, aspartate aminotransferase. **Statistically significant (Mann-Whitney U test, p<0.01). [dagger]Total count number (cells/mm3; values are mean (SD)). [double dagger]Percentage.</description><subject>Acute Disease</subject><subject>acute hepatitis</subject><subject>Adult</subject><subject>CD4+/CD25</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Genotype & phenotype</subject><subject>Hepatitis</subject><subject>Hepatitis C - immunology</subject><subject>hepatitis C virus</subject><subject>Hepatitis C, Chronic - immunology</subject><subject>Humans</subject><subject>Infections</subject><subject>Interferon</subject><subject>Letters</subject><subject>Liver</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Receptors, Interleukin-2 - analysis</subject><subject>Studies</subject><subject>T regulatory lymphocytes</subject><subject>T-Lymphocyte Subsets - immunology</subject><issn>0017-5749</issn><issn>1468-3288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqFkc2P0zAQxS0EYrsLZ27IEhKHXaW14yS2L0goXT5EtVwKV8u1x21K6nRtp2L_exKlWj4unOYwv3kzbx5CryiZU8qqxbZP85yQak6kFII_QTNaVCJjuRBP0YwQyrOSF_ICXca4J4QIIelzdEErSUpO6QzZ2xZOOoHF9bK4WdTLvLzBa2ygbbELcN-DNw9Ye4td701qOo9tHxq_xdr0CfAOjjo1qYm4xscAUW8Bm13ofGMwnLq2H0deoGdOtxFenusV-vbhdl1_ylZfP36u36-yTSHzlDGuhWGWgxVQWGedIHYjtXPA8kpyQyrBKXdWa-GIlRsHOYNKS1kQlwvp2BV6N-ke-80BrAGfgm7VMTQHHR5Upxv1d8c3O7XtToqKipCCDgJvzwKhG6zHpA5NHH-hPXR9VMMBBc2pHMA3_4D7rg9-MKco55KxkpFRbjFRJnQxBnCPp1CixvzUkJ8a81NTfsPE6z8d_ObPgQ1ANgFNTPDzsa_DD1Vxxkt1971WX9ZlvZLLO5UP_PXEbw77_27_BY4ws_4</recordid><startdate>200609</startdate><enddate>200609</enddate><creator>Perrella, A</creator><creator>Vitiello, L</creator><creator>Atripaldi, L</creator><creator>Conti, P</creator><creator>Sbreglia, C</creator><creator>Altamura, S</creator><creator>Patarino, T</creator><creator>Vela, R</creator><creator>Morelli, G</creator><creator>Bellopede, P</creator><creator>Alone, C</creator><creator>Racioppi, L</creator><creator>Perrella, O</creator><general>BMJ Publishing Group Ltd and British Society of Gastroenterology</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200609</creationdate><title>Elevated CD4+/CD25+ T cell frequency and function during acute hepatitis C presage chronic evolution</title><author>Perrella, A ; Vitiello, L ; Atripaldi, L ; Conti, P ; Sbreglia, C ; Altamura, S ; Patarino, T ; Vela, R ; Morelli, G ; Bellopede, P ; Alone, C ; Racioppi, L ; Perrella, O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b492t-37a8c3d7ed8e4dfdf80db9affe32697c068717fdaa8f0d9bfe23e6a9940f289f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Acute Disease</topic><topic>acute hepatitis</topic><topic>Adult</topic><topic>CD4+/CD25</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Genotype & phenotype</topic><topic>Hepatitis</topic><topic>Hepatitis C - immunology</topic><topic>hepatitis C virus</topic><topic>Hepatitis C, Chronic - immunology</topic><topic>Humans</topic><topic>Infections</topic><topic>Interferon</topic><topic>Letters</topic><topic>Liver</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Receptors, Interleukin-2 - analysis</topic><topic>Studies</topic><topic>T regulatory lymphocytes</topic><topic>T-Lymphocyte Subsets - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perrella, A</creatorcontrib><creatorcontrib>Vitiello, L</creatorcontrib><creatorcontrib>Atripaldi, L</creatorcontrib><creatorcontrib>Conti, P</creatorcontrib><creatorcontrib>Sbreglia, C</creatorcontrib><creatorcontrib>Altamura, S</creatorcontrib><creatorcontrib>Patarino, T</creatorcontrib><creatorcontrib>Vela, R</creatorcontrib><creatorcontrib>Morelli, G</creatorcontrib><creatorcontrib>Bellopede, P</creatorcontrib><creatorcontrib>Alone, C</creatorcontrib><creatorcontrib>Racioppi, L</creatorcontrib><creatorcontrib>Perrella, O</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Gut</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perrella, A</au><au>Vitiello, L</au><au>Atripaldi, L</au><au>Conti, P</au><au>Sbreglia, C</au><au>Altamura, S</au><au>Patarino, T</au><au>Vela, R</au><au>Morelli, G</au><au>Bellopede, P</au><au>Alone, C</au><au>Racioppi, L</au><au>Perrella, O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated CD4+/CD25+ T cell frequency and function during acute hepatitis C presage chronic evolution</atitle><jtitle>Gut</jtitle><addtitle>Gut</addtitle><date>2006-09</date><risdate>2006</risdate><volume>55</volume><issue>9</issue><spage>1370</spage><epage>1371</epage><pages>1370-1371</pages><issn>0017-5749</issn><eissn>1468-3288</eissn><coden>GUTTAK</coden><abstract>Table 1 Patient characteristics Parameter HCV-T0 HCV-T6 HAV HD Age (y) (mean (SD)) 42 (3) 40 (2) 32 (5) 35 (6) Sex (M/F) 10/6 12/12 11/4 7/3 ALT level (U/l <40) 1425 (539) 100 (50) 1418 (543) <40 AST level (U/l <40) 892 (305) 84 (24) 851 (221) <40 HCV-RNA (IU/ml (mean (SD)) 310 (232)x103 Positive na na Genotype 1a/1b 12/16 11/12 0 Non-1 4/16 1/12 Mode of infection Needlestick 1/16 0 Surgery procedure 2/16 0 Alimentary 0 15/15 Unclear 13/16 0 Immunological parameters CD3+ CD4+ 956 (297)[dagger]** 892 (103) 725 (200)** 772 (297)** CD3+ CD4+ CD25+ 130 (50)[dagger]** 111 (12) 46 (26)** 46 (13)** CD3+ CD4+ CD25+ 13.5 (3)[double dagger]** 11.2 (2) 6.3 (1)** 6 (1)** T regulatory functional assay¶ Ratio 1:2¶ 100§** 92 80 79 Ratio 1:20 99** 85** 70 55 HCV-T0, patients with hepatitis C virus at time 0; HCV-T6, patients hepatitis C virus after six months; HAV, patients with acute hepatitis A; HD, healthy donors; na, not applicable; ALT, alanine aminotransferase; AST, aspartate aminotransferase. **Statistically significant (Mann-Whitney U test, p<0.01). [dagger]Total count number (cells/mm3; values are mean (SD)). [double dagger]Percentage.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and British Society of Gastroenterology</pub><pmid>16905711</pmid><doi>10.1136/gut.2006.099887</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Disease acute hepatitis Adult CD4+/CD25 CD4-Positive T-Lymphocytes - immunology Disease Progression Female Genotype & phenotype Hepatitis Hepatitis C - immunology hepatitis C virus Hepatitis C, Chronic - immunology Humans Infections Interferon Letters Liver Lymphocytes Male Middle Aged Prognosis Receptors, Interleukin-2 - analysis Studies T regulatory lymphocytes T-Lymphocyte Subsets - immunology |
| title | Elevated CD4+/CD25+ T cell frequency and function during acute hepatitis C presage chronic evolution |
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