Cytokeratin subtyping to distinguish reactive and neoplastic RPE cells

Consistent with neoplasia in other simple epithelia,, I). [...]the pattern of CK in the present specimen, with loss of CK8/18 and gain of CK7, is consistent with that of hyperplastic rather than neoplastic RPE. [...]the final histological diagnosis was CNV of inflammatory aetiology with associated R...

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Bibliographic Details
Published in:British journal of ophthalmology 2006-06, Vol.90 (6), p.801-802
Main Authors: Guerin, E P, Wong, D, Silvestri, G, Hiscott, P S
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - analysis
Child
cytokeratin
Diagnosis, Differential
Female
Humans
hyperplasia
Hyperplasia - diagnosis
Keratins - analysis
Letter
Macular degeneration
neoplasia
Pigment Epithelium of Eye - pathology
Retinal Neoplasms - diagnosis
retinal pigment epithelium
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Description
Summary:Consistent with neoplasia in other simple epithelia,, I). [...]the pattern of CK in the present specimen, with loss of CK8/18 and gain of CK7, is consistent with that of hyperplastic rather than neoplastic RPE. [...]the final histological diagnosis was CNV of inflammatory aetiology with associated RPE gross hyperplasia.
ISSN:0007-1161
1468-2079
DOI:10.1136/bjo.2006.090795