Comparison of the haemodynamics of different pacing sites in patients undergoing resynchronisation treatment: need for individualisation of lead localisation

Background: Biventricular pacing is a new therapy for the treatment of heart failure. However, a substantial number of patients do not respond to this therapy. Hypothesis: Individually determined maximal pacing sites will improve the haemodynamic response and increase the number of responders. Metho...

Full description

Saved in:
Bibliographic Details
Published in:Heart (British Cardiac Society) 2006-12, Vol.92 (12), p.1795-1800
Main Authors: van Campen, C M C, Visser, F C, de Cock, C C, Vos, H S, Kamp, O, Visser, C A
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
atrioventricular
Cardiac arrhythmia
Cardiac Output - physiology
Cardiac Pacing, Artificial - methods
Cardiovascular Medicine
Echocardiography, Doppler
Electrocardiography
Female
Flow velocity
Heart attacks
Heart failure
Heart Failure - physiopathology
Heart Failure - therapy
Heart rate
Humans
Localization
Male
Middle Aged
Multivariate analysis
New York Heart Association
NYHA
Patients
right ventricular outflow tract
RVOT
Studies
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Biventricular pacing is a new therapy for the treatment of heart failure. However, a substantial number of patients do not respond to this therapy. Hypothesis: Individually determined maximal pacing sites will improve the haemodynamic response and increase the number of responders. Methods: In 48 patients with heart failure, the acute haemodynamic effects of nine different pacing configurations were studied, using two right and left ventricular pacing sites and their combinations. Cardiac index was measured using Doppler echocardiography. For further analysis, the combination with the highest cardiac index improvement was compared with baseline. Moreover, the number of responders was calculated using a cut-off value of 10% increase in cardiac index. Results: The mean (SD) increase in cardiac index ranged between 3.8% (6.0%) and 11.1% (8.6%). The pacing site with maximal cardiac index was highly variable between patients, and here the cardiac index increased to 14.8% (7.6%; (p
ISSN:1355-6037
1468-201X
DOI:10.1136/hrt.2004.050435