Simplified detection of microsatellite instability in colorectal cancer without the need for corresponding germline DNA analysis

A panel of five quasimonomorphic mononucleotide repeats that dispenses with the need to analyse corresponding germline DNA was proposed by Suraweera et al for the detection of high-frequency microsatellite instability (MSI) in colorectal cancer. Using this panel, a simplified and a more sensitive (c...

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Bibliographic Details
Published in:Journal of clinical pathology 2006-10, Vol.59 (10), p.1114-1115
Main Authors: Ebinger, M, Sotlar, K, Weber, A, Bock, C T, Bültmann, B D, Kandolf, R
Format: Article
Language:English
Subjects:
Algorithms
Biological and medical sciences
Colorectal Neoplasms - genetics
DNA, Neoplasm - genetics
Gastroenterology. Liver. Pancreas. Abdomen
Genomic Instability
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
microsatellite instability
Microsatellite Repeats - genetics
microsatellite stable
mononucleotide repeat pentaplex
MRP
MSI
MSS
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
PCR polymerase chain reaction
Polymerase Chain Reaction - methods
Retrospective Studies
Sensitivity and Specificity
Short Report
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:A panel of five quasimonomorphic mononucleotide repeats that dispenses with the need to analyse corresponding germline DNA was proposed by Suraweera et al for the detection of high-frequency microsatellite instability (MSI) in colorectal cancer. Using this panel, a simplified and a more sensitive (compared with the original) algorithm (p
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.2005.028217