Loading…

Electroconvulsive shock enhances striatal dopamine D1 and D3 receptor binding and improves motor performance in 6-OHDA-lesioned rats

Objective Electroconvulsive therapy (ECT) is a widely used and effective treatment for mood disorders and appears to have positive effects on the motor symptoms of Parkinson’s disease (PD), improving motor function for several weeks. Because repeated electroconvulsive shock (ECS) in normal animals e...

Full description

Saved in:
Bibliographic Details
Published in:Journal of psychiatry & neuroscience 2007-05, Vol.32 (3), p.193-202
Main Authors: Strome, Elissa M, Zis, Athanasios P, Doudet, Doris J
Format: Article
Language:English
Subjects:
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 202
container_issue 3
container_start_page 193
container_title Journal of psychiatry & neuroscience
container_volume 32
creator Strome, Elissa M
Zis, Athanasios P
Doudet, Doris J
description Objective Electroconvulsive therapy (ECT) is a widely used and effective treatment for mood disorders and appears to have positive effects on the motor symptoms of Parkinson’s disease (PD), improving motor function for several weeks. Because repeated electroconvulsive shock (ECS) in normal animals enhances striatal dopamine (DA) D1 and D3 receptor binding, we hypothesized that upregulation of D1 and D3 receptors may also be occurring in the parkinsonian brain after repeated ECS treatment. Methods Rats were rendered hemiparkinsonian through unilateral infusion of the DA-specific neurotoxin 6-hydroxydopamine into the medial forebrain bundle and substantia nigra. The animals were tested for hindlimb and forelimb function before and 48 hours after the last of 10 daily treatments with ECS or sham. After sacrifice, DA receptor binding was determined autoradiographically. Results While there was no increase in forelimb use in the cylinder test, ECS treatment significantly improved hindlimb motor performance on a tapered beam-walking test and enhanced striatal D1 and D3 receptor binding, without affecting D2 receptor binding. Conclusion This study suggests that at least part of the mechanism of action of ECT in PD may be enhanced DA function within the direct pathway of the basal ganglia and may support the further study and use of ECT as a potential adjunct treatment for PD.
doi_str_mv 10.1016/S1180-4882(07)50030-2
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1863551</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S1180488207500302</els_id><sourcerecordid>70455900</sourcerecordid><originalsourceid>FETCH-LOGICAL-e1941-79ba325000b26fa49beeae16f07cec639dfda9cbccdc2ced3896660d3a4296023</originalsourceid><addsrcrecordid>eNpVkk1v1DAQhi0Eou3CTwD5AoJDwF9xkkulqttSpEo9AGfLsSddt44d7Gyk3vnheJcthZOtmWfesd8ZhN5Q8okSKj9_o7QllWhb9oE0H2tCOKnYM3RMS6higovn5f6IHKGTnO8IIYzQ-iU6oo1oJJfyGP268GDmFE0My9ZntwDOm2juMYSNDgYyznNyetYe2zjp0QXAa4p1sHjNcQID0xwT7l2wLtzu426cUlxK5Rh3qQnSENO4E8MuYFndXK3PKg_ZxQAWJz3nV-jFoH2G14dzhX5cXnw_v6qub758PT-7roB2glZN12vOyldJz-SgRdcDaKByII0BI3lnB6s70xtjDTNgedtJKYnlWrBOEsZX6PSP7rTtR7AGwpy0V1Nyo04PKmqn_s8Et1G3cVG0lbyuaRF4fxBI8ecW8qxGlw14rwPEbVYNEXXdlVms0Nt_O_1t8Wh8Ad4dAJ2N9kMq_rj8xLUFFKJ-ejIUXxYHSRnvgisl9_AA-S5uUyiWKaoyU0Ttt2I3cdLsV4Lx31fxqzg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70455900</pqid></control><display><type>article</type><title>Electroconvulsive shock enhances striatal dopamine D1 and D3 receptor binding and improves motor performance in 6-OHDA-lesioned rats</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Strome, Elissa M ; Zis, Athanasios P ; Doudet, Doris J</creator><creatorcontrib>Strome, Elissa M ; Zis, Athanasios P ; Doudet, Doris J</creatorcontrib><description>Objective Electroconvulsive therapy (ECT) is a widely used and effective treatment for mood disorders and appears to have positive effects on the motor symptoms of Parkinson’s disease (PD), improving motor function for several weeks. Because repeated electroconvulsive shock (ECS) in normal animals enhances striatal dopamine (DA) D1 and D3 receptor binding, we hypothesized that upregulation of D1 and D3 receptors may also be occurring in the parkinsonian brain after repeated ECS treatment. Methods Rats were rendered hemiparkinsonian through unilateral infusion of the DA-specific neurotoxin 6-hydroxydopamine into the medial forebrain bundle and substantia nigra. The animals were tested for hindlimb and forelimb function before and 48 hours after the last of 10 daily treatments with ECS or sham. After sacrifice, DA receptor binding was determined autoradiographically. Results While there was no increase in forelimb use in the cylinder test, ECS treatment significantly improved hindlimb motor performance on a tapered beam-walking test and enhanced striatal D1 and D3 receptor binding, without affecting D2 receptor binding. Conclusion This study suggests that at least part of the mechanism of action of ECT in PD may be enhanced DA function within the direct pathway of the basal ganglia and may support the further study and use of ECT as a potential adjunct treatment for PD.</description><identifier>ISSN: 1180-4882</identifier><identifier>EISSN: 1488-2434</identifier><identifier>DOI: 10.1016/S1180-4882(07)50030-2</identifier><identifier>PMID: 17476366</identifier><language>eng</language><publisher>Ottawa, ON: Canadian Medical Association</publisher><subject>Animals ; Binding, Competitive ; Biological and medical sciences ; Corpus Striatum - metabolism ; Disease Models, Animal ; Electroconvulsive Therapy - methods ; Fundamental and applied biological sciences. Psychology ; Male ; Medical Education ; Medical sciences ; Oxidopamine ; Parkinsonian Disorders - chemically induced ; Parkinsonian Disorders - therapy ; Psychiatry ; Psychoanalysis ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychomotor Performance - physiology ; Psychopathology. Psychiatry ; Rats ; Rats, Sprague-Dawley ; Receptors, Dopamine D1 - metabolism ; Receptors, Dopamine D3 - metabolism ; Research Paper ; Sympatholytics</subject><ispartof>Journal of psychiatry &amp; neuroscience, 2007-05, Vol.32 (3), p.193-202</ispartof><rights>Canadian Medical Association</rights><rights>2007 INIST-CNRS</rights><rights>2007 Canadian Medical Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1863551/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1863551/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,37013,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=18747445$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17476366$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Strome, Elissa M</creatorcontrib><creatorcontrib>Zis, Athanasios P</creatorcontrib><creatorcontrib>Doudet, Doris J</creatorcontrib><title>Electroconvulsive shock enhances striatal dopamine D1 and D3 receptor binding and improves motor performance in 6-OHDA-lesioned rats</title><title>Journal of psychiatry &amp; neuroscience</title><addtitle>J Psychiatry Neurosci</addtitle><description>Objective Electroconvulsive therapy (ECT) is a widely used and effective treatment for mood disorders and appears to have positive effects on the motor symptoms of Parkinson’s disease (PD), improving motor function for several weeks. Because repeated electroconvulsive shock (ECS) in normal animals enhances striatal dopamine (DA) D1 and D3 receptor binding, we hypothesized that upregulation of D1 and D3 receptors may also be occurring in the parkinsonian brain after repeated ECS treatment. Methods Rats were rendered hemiparkinsonian through unilateral infusion of the DA-specific neurotoxin 6-hydroxydopamine into the medial forebrain bundle and substantia nigra. The animals were tested for hindlimb and forelimb function before and 48 hours after the last of 10 daily treatments with ECS or sham. After sacrifice, DA receptor binding was determined autoradiographically. Results While there was no increase in forelimb use in the cylinder test, ECS treatment significantly improved hindlimb motor performance on a tapered beam-walking test and enhanced striatal D1 and D3 receptor binding, without affecting D2 receptor binding. Conclusion This study suggests that at least part of the mechanism of action of ECT in PD may be enhanced DA function within the direct pathway of the basal ganglia and may support the further study and use of ECT as a potential adjunct treatment for PD.</description><subject>Animals</subject><subject>Binding, Competitive</subject><subject>Biological and medical sciences</subject><subject>Corpus Striatum - metabolism</subject><subject>Disease Models, Animal</subject><subject>Electroconvulsive Therapy - methods</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Medical Education</subject><subject>Medical sciences</subject><subject>Oxidopamine</subject><subject>Parkinsonian Disorders - chemically induced</subject><subject>Parkinsonian Disorders - therapy</subject><subject>Psychiatry</subject><subject>Psychoanalysis</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychomotor Performance - physiology</subject><subject>Psychopathology. Psychiatry</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Dopamine D1 - metabolism</subject><subject>Receptors, Dopamine D3 - metabolism</subject><subject>Research Paper</subject><subject>Sympatholytics</subject><issn>1180-4882</issn><issn>1488-2434</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNpVkk1v1DAQhi0Eou3CTwD5AoJDwF9xkkulqttSpEo9AGfLsSddt44d7Gyk3vnheJcthZOtmWfesd8ZhN5Q8okSKj9_o7QllWhb9oE0H2tCOKnYM3RMS6higovn5f6IHKGTnO8IIYzQ-iU6oo1oJJfyGP268GDmFE0My9ZntwDOm2juMYSNDgYyznNyetYe2zjp0QXAa4p1sHjNcQID0xwT7l2wLtzu426cUlxK5Rh3qQnSENO4E8MuYFndXK3PKg_ZxQAWJz3nV-jFoH2G14dzhX5cXnw_v6qub758PT-7roB2glZN12vOyldJz-SgRdcDaKByII0BI3lnB6s70xtjDTNgedtJKYnlWrBOEsZX6PSP7rTtR7AGwpy0V1Nyo04PKmqn_s8Et1G3cVG0lbyuaRF4fxBI8ecW8qxGlw14rwPEbVYNEXXdlVms0Nt_O_1t8Wh8Ad4dAJ2N9kMq_rj8xLUFFKJ-ejIUXxYHSRnvgisl9_AA-S5uUyiWKaoyU0Ttt2I3cdLsV4Lx31fxqzg</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Strome, Elissa M</creator><creator>Zis, Athanasios P</creator><creator>Doudet, Doris J</creator><general>Canadian Medical Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20070501</creationdate><title>Electroconvulsive shock enhances striatal dopamine D1 and D3 receptor binding and improves motor performance in 6-OHDA-lesioned rats</title><author>Strome, Elissa M ; Zis, Athanasios P ; Doudet, Doris J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e1941-79ba325000b26fa49beeae16f07cec639dfda9cbccdc2ced3896660d3a4296023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Binding, Competitive</topic><topic>Biological and medical sciences</topic><topic>Corpus Striatum - metabolism</topic><topic>Disease Models, Animal</topic><topic>Electroconvulsive Therapy - methods</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Medical Education</topic><topic>Medical sciences</topic><topic>Oxidopamine</topic><topic>Parkinsonian Disorders - chemically induced</topic><topic>Parkinsonian Disorders - therapy</topic><topic>Psychiatry</topic><topic>Psychoanalysis</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychomotor Performance - physiology</topic><topic>Psychopathology. Psychiatry</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Dopamine D1 - metabolism</topic><topic>Receptors, Dopamine D3 - metabolism</topic><topic>Research Paper</topic><topic>Sympatholytics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Strome, Elissa M</creatorcontrib><creatorcontrib>Zis, Athanasios P</creatorcontrib><creatorcontrib>Doudet, Doris J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of psychiatry &amp; neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Strome, Elissa M</au><au>Zis, Athanasios P</au><au>Doudet, Doris J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electroconvulsive shock enhances striatal dopamine D1 and D3 receptor binding and improves motor performance in 6-OHDA-lesioned rats</atitle><jtitle>Journal of psychiatry &amp; neuroscience</jtitle><addtitle>J Psychiatry Neurosci</addtitle><date>2007-05-01</date><risdate>2007</risdate><volume>32</volume><issue>3</issue><spage>193</spage><epage>202</epage><pages>193-202</pages><issn>1180-4882</issn><eissn>1488-2434</eissn><abstract>Objective Electroconvulsive therapy (ECT) is a widely used and effective treatment for mood disorders and appears to have positive effects on the motor symptoms of Parkinson’s disease (PD), improving motor function for several weeks. Because repeated electroconvulsive shock (ECS) in normal animals enhances striatal dopamine (DA) D1 and D3 receptor binding, we hypothesized that upregulation of D1 and D3 receptors may also be occurring in the parkinsonian brain after repeated ECS treatment. Methods Rats were rendered hemiparkinsonian through unilateral infusion of the DA-specific neurotoxin 6-hydroxydopamine into the medial forebrain bundle and substantia nigra. The animals were tested for hindlimb and forelimb function before and 48 hours after the last of 10 daily treatments with ECS or sham. After sacrifice, DA receptor binding was determined autoradiographically. Results While there was no increase in forelimb use in the cylinder test, ECS treatment significantly improved hindlimb motor performance on a tapered beam-walking test and enhanced striatal D1 and D3 receptor binding, without affecting D2 receptor binding. Conclusion This study suggests that at least part of the mechanism of action of ECT in PD may be enhanced DA function within the direct pathway of the basal ganglia and may support the further study and use of ECT as a potential adjunct treatment for PD.</abstract><cop>Ottawa, ON</cop><pub>Canadian Medical Association</pub><pmid>17476366</pmid><doi>10.1016/S1180-4882(07)50030-2</doi><tpages>10</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1180-4882
ispartof Journal of psychiatry & neuroscience, 2007-05, Vol.32 (3), p.193-202
issn 1180-4882
1488-2434
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1863551
source Publicly Available Content Database; PubMed Central
subjects Animals
Binding, Competitive
Biological and medical sciences
Corpus Striatum - metabolism
Disease Models, Animal
Electroconvulsive Therapy - methods
Fundamental and applied biological sciences. Psychology
Male
Medical Education
Medical sciences
Oxidopamine
Parkinsonian Disorders - chemically induced
Parkinsonian Disorders - therapy
Psychiatry
Psychoanalysis
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Psychomotor Performance - physiology
Psychopathology. Psychiatry
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D1 - metabolism
Receptors, Dopamine D3 - metabolism
Research Paper
Sympatholytics
title Electroconvulsive shock enhances striatal dopamine D1 and D3 receptor binding and improves motor performance in 6-OHDA-lesioned rats
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T09%3A48%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Electroconvulsive%20shock%20enhances%20striatal%20dopamine%20D1%20and%20D3%20receptor%20binding%20and%20improves%20motor%20performance%20in%206-OHDA-lesioned%20rats&rft.jtitle=Journal%20of%20psychiatry%20&%20neuroscience&rft.au=Strome,%20Elissa%20M&rft.date=2007-05-01&rft.volume=32&rft.issue=3&rft.spage=193&rft.epage=202&rft.pages=193-202&rft.issn=1180-4882&rft.eissn=1488-2434&rft_id=info:doi/10.1016/S1180-4882(07)50030-2&rft_dat=%3Cproquest_pubme%3E70455900%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-e1941-79ba325000b26fa49beeae16f07cec639dfda9cbccdc2ced3896660d3a4296023%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=70455900&rft_id=info:pmid/17476366&rfr_iscdi=true