Diagnostic and prognostic significance of genetic regional heterogeneity in meningiomas1

We analyzed the frequency and regional distribution of cells with genetic abnormalities of chromosomes 1, 14, and 22 in meningiomas. This data was evaluated for correlation to the clinical outcome of the patients. Eight defined areas of each of 77 paraffin-embedded meningioma samples (59 grade I, 13...

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Bibliographic Details
Published in:Neuro-oncology (Charlottesville, Va.) Va.), 2004-10, Vol.6 (4), p.290-299
Main Authors: Pfisterer, Wolfgang K., Hank, Nicole C., Preul, Mark C., Hendricks, William P., Pueschel, Jeanette, Coons, Stephen W., Scheck, Adrienne C.
Format: Article
Language:English
Subjects:
Basic and Translational Investigations
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Summary:We analyzed the frequency and regional distribution of cells with genetic abnormalities of chromosomes 1, 14, and 22 in meningiomas. This data was evaluated for correlation to the clinical outcome of the patients. Eight defined areas of each of 77 paraffin-embedded meningioma samples (59 grade I, 13 grade II, and 5 grade III) were analyzed by fluorescent in situ hybridization using bacterial artificial chromosome probes localized to chromosomes 1p36.32, 1q25.3, 14q13.3, 14q32.12, 22q11.2, and 22q12.1-3. Chromosome deletion was considered to be regionally heterogeneous if
ISSN:1522-8517
1523-5866
DOI:10.1215/S1152851704000158