Receptor pharmacogenetics: relevance to CNS syndromes

Pharmacogenetic research dedicated to the investigation of inherited factors that influence drug response has produced exciting results over the past decade. Adding to the knowledge that genetic variation in metabolic enzymes may cause drug‐related adverse reactions, recent studies indicate that var...

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Bibliographic Details
Published in:British journal of clinical pharmacology 2002-10, Vol.54 (4), p.344-348
Main Authors: Shaikh, Sanober, Kerwin, Robert W.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Central Nervous System Diseases - genetics
Cholinergic Fibers - physiology
General pharmacology
Genome, Human
Humans
individualization of treatment
Medical sciences
Neurotransmitter Agents - physiology
neurotransmitter receptors
pharmacogenomics
Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
Pharmacology. Drug treatments
Receptors, Dopamine - genetics
Receptors, Neurotransmitter - genetics
Review Series
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Summary:Pharmacogenetic research dedicated to the investigation of inherited factors that influence drug response has produced exciting results over the past decade. Adding to the knowledge that genetic variation in metabolic enzymes may cause drug‐related adverse reactions, recent studies indicate that variation in neurotransmitter receptors can also be the cause of treatment failure. In addition, recent studies have attempted to use genetic information for the prediction of treatment outcome. The aim of this review is to summarize the most significant findings in pharmacogenetic research in relation to CNS drugs and to outline how these studies could lead to the individualization of drug treatment.
ISSN:0306-5251
1365-2125
DOI:10.1046/j.1365-2125.2002.01679.x