Hyperparathyroidism in pregnancy: case report and review of the literature

• Published in: Canadian Medical Association journal 1983-11, Vol.129 (9), p.986-989
• Main Authors: Wilson, R. D, Martin, T, Christensen, R, Yee, A. H, Reynolds, C
• Format: Article
• Language: English
• Subjects: Adenoma - complications; Administration, Oral; Adult; Calcium - blood; Female; Fetal Death - etiology; Humans; Hypercalcemia - etiology; Hyperparathyroidism - diagnosis; Hyperparathyroidism - therapy; Infant, Newborn; Infant, Newborn, Diseases - etiology; Male; Parathyroid Hormone - blood; Parathyroid Neoplasms - complications; Phosphates - administration & dosage; Pregnancy; Pregnancy Complications - diagnosis; Pregnancy Complications - therapy; Tetany - etiology
• ISSN: 0008-4409

The apparent incidence of hyperparathyroidism (HPT) is low in pregnancy but will likely increase now that more asymptomatic HPT is being diagnosed. However, since the serum calcium levels are decreased in pregnant women, mild primary HPT may go unrecognized. In untreated cases of HPT, complications during pregnancy or during the neonatal period have included spontaneous abortion, stillbirth, neonatal death, neonatal tetany and hypercalcemia. A review of the literature indicates a substantial improvement in fetal outcome when parathyroidectomy is done during pregnancy, as in the case reported here. Therefore, parathyroidectomy is the treatment of choice when the diagnosis is made during pregnancy, although oral phosphate therapy may be an alternative if surgery is contraindicated.