Possible mechanisms of normal amylase activity in hyperlipemic pancreatitis

Lipemic serum from three patients with acute pancreatitis and type IV hyperlipemia was fractionated into very-low-density lipoproteins and clear serum. Amylase activity (determined by the Phadebas method) in the component fractions did not exceed that in the original lipemic serum. Addition of these...

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Bibliographic Details
Published in:Canadian Medical Association journal 1976-11, Vol.115 (10), p.1016-1019
Main Authors: Mishkin, S, Bates, J, O'Hashi, J, Schneider, P, Sniderman, A. D, Wolf, R. O
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Amylases - antagonists & inhibitors
Amylases - blood
Chylomicrons - metabolism
Female
Humans
Hyperlipidemias - enzymology
Hyperlipidemias - etiology
Isoamylase - analysis
Lipoproteins, VLDL - blood
Lipoproteins, VLDL - metabolism
Male
Pancreatitis - complications
Pancreatitis - enzymology
Protein Binding
Triglycerides - blood
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Summary:Lipemic serum from three patients with acute pancreatitis and type IV hyperlipemia was fractionated into very-low-density lipoproteins and clear serum. Amylase activity (determined by the Phadebas method) in the component fractions did not exceed that in the original lipemic serum. Addition of these fractions or VLDL and chylomicrons from asymptomatic patients with hyperlipemia to nonlipemic serum from patients with "routine acute pancreatitis" did not inhibit amylase activity or alter the electrophoretic mobility of amylase isoenzymes. Therefore the normal amylase activity often observed in hyperlipemic pancreatitis does not result from an inhibition of amylase activity by serum lipoproteins.
ISSN:0008-4409