Controlled low protein diets in chronic renal insufficiency: meta-analysis

• Published in: BMJ 1992-01, Vol.304 (6821), p.216-220
• Main Authors: Fouque, D., Laville, M., Boissel, J. P., Chifflet, R., Labeeuw, M., Zech, P. Y.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Chronic kidney failure; Control groups; Diabetic nephropathies; Dialysis; Diet; Dietary Proteins - administration & dosage; Experimentation; Female; Follow-Up Studies; Humans; Kidney Failure, Chronic - diet therapy; Kidney Failure, Chronic - mortality; Kidney Failure, Chronic - therapy; Kidneys; Low protein diets; Male; Meta-Analysis as Topic; Middle Aged; Protein intake; Randomized Controlled Trials as Topic; Renal Dialysis; Renal function
• ISSN: 0959-8138; 1468-5833; 1756-1833
• DOI: 10.1136/bmj.304.6821.216

OBJECTIVE--To determine whether low protein diets retard the development of end stage renal disease. DESIGN--Meta-analysis of 46 trials since 1975, from which six randomised controlled trials were selected. SETTING--Five trials in Europe and one in Australia between 1982 and 1991. SUBJECTS--890 patients with mild to severe chronic renal failure who were followed up for at least one year. 450 patients received a low protein diet and 440 a control diet. INTERVENTION--Difference in protein intake between control and treated groups of at least 0.2 g protein/kg/day. MAIN OUTCOME MEASURE--Number of renal deaths (the necessity to start dialysis or death of patient during study). RESULTS--156 renal deaths were recorded, 61 in the low protein diet group and 95 in the control group, leading to an odds ratio of low protein to control of 0.54 with a 95% confidence interval of 0.37 to 0.79. CONCLUSIONS--This result, obtained on a large population of patients suffering from chronic renal insufficiency, strongly supports the effectiveness of low protein diets in delaying the onset of end stage renal disease.