Cholesterol crystallisation in bile

The concentration of biliary lipids then increases and high bile salt concentrations promote mixed micelle formation with growth of cholesterol-rich vesicles. [...]vesicular cholesterol is important for cholesterol crystal formation. 25 Recent studies in cholesterol fed prairie dogs, however, have s...

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Bibliographic Details
Published in:Gut 1997-08, Vol.41 (2), p.138-141
Main Authors: PORTINCASA, P, VAN ERPECUM, K J, VANBERGE-HENEGOUWEN, G P
Format: Article
Language:English
Subjects:
Bile
Bile - chemistry
Biological and medical sciences
Bladder
Cholelithiasis - metabolism
Cholesterol
Cholesterol - chemistry
Crystallization
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Leading
Lipids
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Microscopy
Molecular weight
Other diseases. Semiology
Proteins
Rodents
Studies
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Summary:The concentration of biliary lipids then increases and high bile salt concentrations promote mixed micelle formation with growth of cholesterol-rich vesicles. [...]vesicular cholesterol is important for cholesterol crystal formation. 25 Recent studies in cholesterol fed prairie dogs, however, have suggested that supersaturated mixed micelles may also have a role in cholesterol crystal precipitation. 26 Biliary proteins and cholesterol crystallisation Bile from patients with cholesterol stones cannot be discriminated from those of control patients simply on the basis of lipid composition. 2 27 28 Thus, other factors, such as biliary proteins, have been suggested to play a part in the pathogenesis of cholesterol crystallisation and stone formation. 29 Although several proteins with cholesterol crystallisation inhibiting as well as promoting properties have been isolated, the active factor has not been identified as yet. [...]gall bladder mucin promotes crystallisation of cholesterol 18 32 33 and mucin hypersecretion precedes cholesterol crystal precipitation and stone formation both in animals 34 35 and humans (such as in obese people with weight reduction and gallstone formation).
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.41.2.138