Three year continuous abstinence in a smoking cessation study using the nicotine transdermal patch

A total of 305 subjects from Sydney were randomly allocated to receive either an active (24 hour transdermal nicotine patch over a 10 week course) or placebo nicotine patch. All subjects participated in a multicomponent cognitive–behavioural smoking cessation programme over five weeks in two-hour gr...

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Bibliographic Details
Published in:Heart (British Cardiac Society) 1997-12, Vol.78 (6), p.617-618
Main Authors: Richmond, Robyn L, Kehoe, Linda, Neto, Abilio Cesar de Almeida
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Behavior Therapy
Biological and medical sciences
Combined Modality Therapy
Confidence intervals
Drug Administration Schedule
Ganglionic Stimulants - administration & dosage
Humans
Medical sciences
Nicotine
Nicotine - administration & dosage
nicotine patches
Short Report
Smoking Cessation
Time Factors
Tobacco, tobacco smoking
Toxicology
Transdermal medication
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Summary:A total of 305 subjects from Sydney were randomly allocated to receive either an active (24 hour transdermal nicotine patch over a 10 week course) or placebo nicotine patch. All subjects participated in a multicomponent cognitive–behavioural smoking cessation programme over five weeks in two-hour group sessions. The continuous abstinence rates at three years (validated by expired carbon monoxide) were 13.8% for the active group and 5.2% for placebo group (p = 0.011). The active nicotine patch with behavioural therapy achieved more than double the abstinence rates early in treatment compared with placebo and this difference was maintained throughout the three year follow up.
ISSN:1355-6037
1468-201X
DOI:10.1136/hrt.78.6.617