Remembering the past and imagining the future: Common and distinct neural substrates during event construction and elaboration

• Published in: Neuropsychologia 2007-01, Vol.45 (7), p.1363-1377
• Main Authors: Addis, Donna Rose, Wong, Alana T., Schacter, Daniel L.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Analysis of Variance; Anatomical correlates of behavior; Autobiographical memory; Autobiography as Topic; Behavioral psychophysiology; Biological and medical sciences; Brain - blood supply; Brain - physiology; Brain Mapping; Cues; Emotions - physiology; Episodic; Female; fMRI; Frontopolar; Functional Laterality; Fundamental and applied biological sciences. Psychology; Hippocampus; Human; Humans; Image Processing, Computer-Assisted - methods; Imagination - physiology; Learning. Memory; Magnetic Resonance Imaging - methods; Male; Memory; Mental Recall - physiology; Oxygen - blood; Photic Stimulation; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Time Factors
• ISSN: 0028-3932; 1873-3514
• DOI: 10.1016/j.neuropsychologia.2006.10.016

People can consciously re-experience past events and pre-experience possible future events. This fMRI study examined the neural regions mediating the construction and elaboration of past and future events. Participants were cued with a noun for 20 s and instructed to construct a past or future event within a specified time period (week, year, 5–20 years). Once participants had the event in mind, they made a button press and for the remainder of the 20 s elaborated on the event. Importantly, all events generated were episodic and did not differ on a number of phenomenological qualities (detail, emotionality, personal significance, field/observer perspective). Conjunction analyses indicated the left hippocampus was commonly engaged by past and future event construction, along with posterior visuospatial regions, but considerable neural differentiation was also observed during the construction phase. Future events recruited regions involved in prospective thinking and generation processes, specifically right frontopolar cortex and left ventrolateral prefrontal cortex, respectively. Furthermore, future event construction uniquely engaged the right hippocampus, possibly as a response to the novelty of these events. In contrast to the construction phase, elaboration was characterized by remarkable overlap in regions comprising the autobiographical memory retrieval network, attributable to the common processes engaged during elaboration, including self-referential processing, contextual and episodic imagery. This striking neural overlap is consistent with findings that amnesic patients exhibit deficits in both past and future thinking, and confirms that the episodic system contributes importantly to imagining the future.