Role of γδ T lymphocytes in the development of Behçet's disease

Phenotypic and functional properties of γδ T cells, which play an important role in mucocutaneous immunity, were examined to elucidate whether immunological abnormality in Behc¸et's disease may be related to a specific T cell population. We found that CD45RA + Vγ9 + Vδ2 + γδ T cells, which cons...

Full description

Saved in:
Bibliographic Details
Published in:Clinical and experimental immunology 1997-02, Vol.107 (2), p.241-247
Main Authors: YAMASHITA, N, KANEOKA, H, KANEKO, S, TAKENO, M, ONEDA, K, KOIZUMI, H, KOGURE, M, INABA, G, SAKANE, T
Format: Article
Language:English
Subjects:
Biological and medical sciences
Medical sciences
Original
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Phenotypic and functional properties of γδ T cells, which play an important role in mucocutaneous immunity, were examined to elucidate whether immunological abnormality in Behc¸et's disease may be related to a specific T cell population. We found that CD45RA + Vγ9 + Vδ2 + γδ T cells, which constitute a minor population of γδ T cells in healthy individuals, were increased in number in Behc¸et's disease irrespective of disease activity. This CD45RA + subset of γδ T cells in the active, but not inactive, phase of this disease expressed IL-2Rβ and HLA-DR, suggesting that they are activated in vivo in active Behc¸et's disease. In addition, the CD45RA + γδ T cells produced extreme amounts of tumour necrosis factor and contained perforin granules. These data indicate that a phenotypically distinct subset of γδ T cells, CD45RA + CD45RO − Vγ9 + Vδ2 + , may contribute to immunological abnormalities which may lead to complexity of pathophysiology in Behc¸et's disease.
ISSN:0009-9104
1365-2249
DOI:10.1111/j.1365-2249.1997.274-ce1159.x