Induction of proinflammatory cytokine and antioxidant enzyme gene expression following brief myocardial ischaemia

The purpose of this study was to determine if proinflammatory cytokines are up‐regulated during reperfusion following sublethal ischaemia, and whether concurrent up‐regulation of antioxidant enzymes occurs. Open‐chest rats were subjected to 15 min of ischaemia followed by 1 or 3 h reperfusion (R). M...

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Bibliographic Details
Published in:Clinical and experimental immunology 1997-05, Vol.108 (2), p.346-351
Main Authors: CHANDRASEKAR, B., COLSTON, J. T., FREEMAN, G. L.
Format: Article
Language:English
Subjects:
Animals
antioxidant enzymes
Antioxidants - metabolism
Biological and medical sciences
Blotting, Northern
Cardiology. Vascular system
Coronary heart disease
Cytokines - biosynthesis
Cytokines - genetics
Enzyme Induction - genetics
gene expression
Gene Expression Regulation, Enzymologic
Glutathione Peroxidase - biosynthesis
Glutathione Peroxidase - genetics
Heart
Immunoblotting
ischaemia
Medical sciences
Myocardial Ischemia - enzymology
Myocardial Ischemia - immunology
Myocardial Ischemia - metabolism
Original
Oxidoreductases - biosynthesis
Oxidoreductases - genetics
proinflammatory cytokines
Rats
Rats, Inbred WKY
reperfusion injury
RNA, Messenger - biosynthesis
Superoxide Dismutase - biosynthesis
Superoxide Dismutase - genetics
Thiobarbituric Acid Reactive Substances - metabolism
Up-Regulation - genetics
Up-Regulation - immunology
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Description
Summary:The purpose of this study was to determine if proinflammatory cytokines are up‐regulated during reperfusion following sublethal ischaemia, and whether concurrent up‐regulation of antioxidant enzymes occurs. Open‐chest rats were subjected to 15 min of ischaemia followed by 1 or 3 h reperfusion (R). Myocardium from the ischaemic zone showed a significantly higher (P 
ISSN:0009-9104
1365-2249
DOI:10.1046/j.1365-2249.1997.d01-1017.x