Immunocytochemical localization of inducible nitric oxide synthase and transforming growth factor‐beta (TGF‐β) in leprosy lesions

Inducible nitric oxide synthase (iNOS) and TGF‐β were localized by immunocytochemistry in skin lesions from patients across the leprosy spectrum, and from patients undergoing reversal reaction. iNOS expression was highest at the tuberculoid pole of the spectrum, and increased during reversal reactio...

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Bibliographic Details
Published in:Clinical and experimental immunology 1998-09, Vol.113 (3), p.438-442
Main Authors: KHANOLKAR-YOUNG, S, SNOWDON, D, LOCKWOOD, D. N. J
Format: Article
Language:English
Subjects:
Bacterial diseases
Biological and medical sciences
Human bacterial diseases
Humans
immunocytochemistry
Immunohistochemistry
Infectious diseases
Leprosy
Leprosy - metabolism
leprosy iNOS
Medical sciences
Mycobacterium leprae
Nitric Oxide Synthase - analysis
Nitric Oxide Synthase Type II
Original
Transforming Growth Factor beta - analysis
Transforming Growth Factor beta - physiology
transforming growth factor‐beta
Tropical bacterial diseases
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Summary:Inducible nitric oxide synthase (iNOS) and TGF‐β were localized by immunocytochemistry in skin lesions from patients across the leprosy spectrum, and from patients undergoing reversal reaction. iNOS expression was highest at the tuberculoid pole of the spectrum, and increased during reversal reaction. TGF‐β was observed throughout the leprosy spectrum, but was highest at the lepromatous pole. Levels of TGF‐β decreased during reversal reaction. Reduced levels of TGF‐β may contribute to unregulated inflammatory responses during reactional episodes.
ISSN:0009-9104
1365-2249
DOI:10.1046/j.1365-2249.1998.00669.x